Miriam E. Bucheli

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The production of a functional mRNA is regulated at every step of transcription. An area not well-understood is the transition of RNA polymerase II from elongation to termination. The S. cerevisiae SR-like protein Npl3 functions to negatively regulate transcription termination by antagonizing the binding of polyA/termination proteins to the mRNA. In this(More)
A team of innovators, contributors, and funders has made this guide possible. Professor Robert Lue initiated the project to improve the teaching of writing in the Life Sciences at Harvard University and has sustained the pro-ject's vision over several years. Produced through col-laborative efforts of the Department of Molecular and Cellular Biology and the(More)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing motor neuron loss and weakness. Worldwide prevalence is 4-6/100,000. Incidence is 1.5-2.7/100,000 per year and may be increasing. Studies suggest race and ethnicity affect the prevalence and incidence of ALS.(1) Understanding the impact of these variables on disease incidence could(More)
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