Mirella Salvatore

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Ideas contained in this document are solely those of the authors and do not necessarily represent the views of FAO or IIASA. The conclusions given in this report are considered appropriate at the time of its preparation. They may be modified in the light of further knowledge gained at subsequent stages of the project. The designations employed and the(More)
Elevated levels of cytokines have been detected in brains of Alzheimer's disease (AD) patients, and altered peripheral levels of IL-1beta, TNFalpha and IL-6 have been reported in these patients. We studied the ability of PBMC from patients with AD, matched with a control group, to release pro- and anti-inflammatory cytokines, and the effect of AChEI(More)
The study evaluates the expression and production of cytokines in peripheral blood mononuclear cells of patients with Alzheimer disease treated or not treated with acetylcholinesterase inhibitor, which enhances neuronal transmission. Cytokines associated with brain inflammation such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha have been(More)
MCP-1 and RANTES are molecules that regulate monocyte and T-lymphocyte recruitment towards sites of inflammation. We sought to evaluate the role of these chemokines in Alzheimer's disease (AD), and the effect of acetylcholinesterase inhibitor (AchEI) therapy on their release from peripheral blood mononuclear cells (PBMC). MCP-1 and RANTES mRNA expressions(More)
Many factors are involved in the pathogenesis of Alzheimer's disease (AD), and inflammatory-immunologic activation seems to play a major role. One strategy for treatment of AD has been to use acetylcholinesterase (AChE) inhibitors to increase the levels of acetylcholine and enhancing cholinergic activity in the affected regions of the brain. Cholinergic(More)
Recent reports highlight the potential for integrase-defective lentiviral vectors (IDLV) to be developed as vaccines due to their ability to elicit cell-mediated and humoral immune responses after intramuscular administration. Differently from their integrase-competent counterpart, whose utility for vaccine development is limited by the potential for(More)
FAO Mapping the vulnerability of mountain peoples to food insecurity For millions of people living in mountainous areas, hunger and the threat of hunger are nothing new. Harsh climates and the difficult, often inaccessible terrain, combined with political and social marginality make mountain peoples vulnerable to food shortages. One in three mountain people(More)
Despite the importance of organic soils, including peatlands, in the global carbon cycle, detailed information on regional and global emissions is scarce. This is due to the difficulty to map, measure, and assess the complex dynamics of land, soil, and water interactions needed to assess the human-driven degradation of organic soils. We produced a new(More)
Since 2001 the Istituto Superiore di Sanità established a quality assurance programme for molecular genetic testing that covers four pathologies: Cystic Fibrosis (CF), Beta Thalassemia (BT), Fragile X Syndrome (FX), and Familial Adenomatous Polyposis Coli (APC). Since 2009 this activity is an institutional activity and participation is open to both public(More)
Riassunto: Negli ultimi anni si è registrato un aumento di interesse (Barro, Sala-i-Martin (1992), Quah (1997)) nei riguardi del tema della convergenza regionale dei redditi pro-capite. Questi autori, però, non considerano il ruolo dell'informazione spaziale nella definizione dei loro modelli. In questo lavoro vengono presentati alcuni modelli di analisi(More)
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