Mirela L Moldovan

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Ultrasonography allows the quantification of dermal density and echogenicity changes during the physiological senescence process. Some active ingredients are able to slow down the tissular degeneration and disorganization process. The purpose of this study was to assess the cutaneous changes induced by the topical use of products containing Viniferol(®) as(More)
In this study three cream formulations were compared in order to assess the influence of different kind of excipients on the skin barrier and stratum corneum hydration. The first cream was formulated based on lipophilic emollients: petrolatum, paraffin oil, cetylstearilic alcohol, cetyl palmitate and paraffin, the second cream was formulated based on(More)
BACKGROUND AND AIMS The main aims of the present study were to formulate an anti-age cream based on vegetal ingredients and ferulic acid and to evaluate the physical characteristics and the efficacy of the cream. METHODS The active ingredients were Centella asiatica oil, Spilanthes acmella oil, Zingiber officinale extract and ferulic acid. Formulation 1(More)
BACKGROUND The aim of this experimental study is to assess the bone healing phenomenon produced in the presence of 3 dental materials used for the root canal obturation. MATERIALS AND METHODS The biocompatibility of 3 endodontic sealers (a self-curing epoxy resin - AH Plus, a dual cure urethane dimethacrylate resin - RealSeal and a new dual cure(More)
OBJECTIVE This study proposed the development of oral lyophilisates with respect to pediatric medicine development guidelines, by applying risk management strategies and DoE as an integrated QbD approach. METHODS Product critical quality attributes were overviewed by generating Ishikawa diagrams for risk assessment purposes, considering process,(More)
With the increasing use of skin cleansing products, the awareness of productsinduced skin irritation, itching, dry skin and other potential effects has also increased. In this paper we studied the influence of some skin cleansers on skin properties that may be influenced by their use: skin surface pH, stratum corneum water content and transepidermal water(More)
PURPOSE Striae distensae represent the result of the failure of the dermis to sustain intrinsic mechanical forces. Intensive moisturization of the lesions and use of emollient oils have been recommended for the prevention and treatment of striae distensae rubra. The aim of this research was to formulate an emollient water-in-oil cosmetic cream containing(More)
The aim of this study was to develop oral lyophilisates with improved meloxicam (MEL) dissolution, optimizing each step of the preparation by design of experiments. First, meloxicam nanosuspensions were prepared by high-pressure homogenization (HPH), using PVP, Poloxamer or PEG as stabilizers and were subjected to freeze-drying using mannitol as(More)
Striae distensae are a frequent skin condition associated with pregnancy, weight change or lack of skin elasticity. The aim of this research was to obtain a topical product containing herbal active ingredients with documented antioxidant and anti-inflammatory activity (Punica granatum seed oil and Croton lechleri resin extract) and demonstrate its positive(More)
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