Mireille Gingras

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Knowledge about the differences in structure, function, and reactivity of the brain and body between Nijmegen high responders to novelty and Nijmegen low responders to novelty may help us to understand which factors give rise to the vulnerability and/or susceptibility to drugs of abuse. For that purpose, this contribution provides a short overview of the(More)
Neurosteroids are a subclass of steroids that can be synthesized in the central nervous system independently from peripheral sources. Clinical studies in humans have associated these hormones with depression and postpartum mood disorders. In rodents, allopregnanolone (AlloP) has been shown to have anxiolytic and rewarding properties. These observations(More)
Susceptibility to behavioural effects of dexamphetamine (0.5-2.0 mg/kg, SC) was analyzed in Nijmegen high responders to novelty (HR) and Nijmegen low responders to novelty (LR), using an automated ethological analysis. The main results were that, first, dexamphetamine was more toxic in HR than LR: 5.0 mg/kg dexamphetamine was lethal in 75% HR, respectively,(More)
The aim of the study was to investigate the biphasic locomotor response to ethanol in rats. Based on the recent finding that high responders to novelty (HR) and low responders to novelty (LR), selected from an outbred Nijmegen Wistar rat population, show differences in ethanol intake and preference, it was initially investigated to what extent HR and LR(More)
Female Swiss-Webster mice were treated daily for 10 days with cocaine (15 mg/kg i.p.) followed by 10 days with saline or ethanol (1.6 g/kg i.p.) or the reverse; following each injection in the experimental conditions locomotion was quantified in photocell cages. In animals given cocaine first, cocaine-induced locomotion was initially high and did not(More)
The aim of the study was to compare locomotor responses to acute and sub-chronic dexamphetamine in two distinct types of Wistar rats, namely the Nijmegen high responders to novelty (HR) and Nijmegen low responders to novelty (LR). HR and LR were chosen because they differ in neurochemical processes relevant to the control of the locomotor effects of(More)
Outbred strains of Wistar rats contain both high responders to novelty (HR) and low responders to novelty (LR). Male HR and LR selected from the Nijmegen outbred strain of Wistar rats differ in their sensitivity to acute administration of dexamphetamine (AMPH). Sub-chronic administration of AMPH sensitizes rats to this agent, and this sensitization (SENS)(More)
Previous studies have shown that stressors attenuate LiCI-induced conditioned taste aversions (CTA) but not morphine-induced CTA. The current studies examined the effects of footshock on the acquisition and extinction of amphetamine-induced CTA. Experiment 1 demonstrated that exposure to 30 footshocks between saccharin consumption and amphetamine injections(More)
Neurosteroids are a subclass of steroids that can be synthesized in the central nervous system independently of peripheral sources. Clinical studies in humans have associated some of these hormones with a generic sensation of 'well-being' and with pathologies such as depression. In rodents, the neurosteroid pregnenolone sulphate (Preg-S) has been shown to(More)
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