Mireille A. Gingras

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 Susceptibility to behavioural effects of dexamphetamine (0.5–2.0 mg/kg, SC) was analyzed in Nijmegen high responders to novelty (HR) and Nijmegen low responders to novelty (LR), using an automated ethological analysis. The main results were that, first, dexamphetamine was more toxic in HR than LR: 5.0 mg/kg dexamphetamine was lethal in 75% HR,(More)
Neurosteroids are a subclass of steroids that can be synthesized in the central nervous system independently from peripheral sources. Clinical studies in humans have associated these hormones with depression and postpartum mood disorders. In rodents, allopregnanolone (AlloP) has been shown to have anxiolytic and rewarding properties. These observations(More)
Neurosteroids are a subclass of steroids that can be synthesized in the central nervous system independently of peripheral sources. Clinical studies in humans have associated some of these hormones with a generic sensation of 'well-being' and with pathologies such as depression. In rodents, the neurosteroid pregnenolone sulphate (Preg-S) has been shown to(More)
Female Swiss-Webster mice were treated daily for 10 days with cocaine (15 mg/kg i.p.) followed by 10 days with saline or ethanol (1.6 g/kg i.p.) or the reverse; following each injection in the experimental conditions locomotion was quantified in photocell cages. In animals given cocaine first, cocaine-induced locomotion was initially high and did not(More)
The aim of the study was to investigate the biphasic locomotor response to ethanol in rats. Based on the recent finding that high responders to novelty (HR) and low responders to novelty (LR), selected from an outbred Nijmegen Wistar rat population, show differences in ethanol intake and preference, it was initially investigated to what extent HR and LR(More)
HBI-3000 (sulcardine sulfate) has been shown to suppress various ventricular arrhythmias in animal models. The electrophysiological properties of HBI-3000 were investigated using standard microelectrode and patch-clamp techniques in single human ventricular myocytes. HBI-3000 led to concentration-dependent suppression of dofetilide-induced early(More)
 Outbred strains of Wistar rats contain both high responders to novelty (HR) and low responders to novelty (LR). Male HR and LR selected from the Nijmegen outbred strain of Wistar rats differ in their sensitivity to acute administration of dexamphetamine (AMPH). Sub-chronic administration of AMPH sensitizes rats to this agent, and this sensitization (SENS)(More)
3529 Background: Chidamide (CS055/HBI-8000) is a new benzamide type of histone deacetylase (HDAC) inhibitor with low nanomolar activity against HDAC1, 2, 3 and 10. This Phase I study evaluated the safety and tolerability of chidamide in patients (pts) with advanced solid tumors and lymphomas. METHODS 31 pts with refractory or relapsed advanced solid(More)
Metanocortins have various physiological actions on the brain. The recent cloning of neural melanecortin 0//(2) receptors Opened new avenues to study the effect of these ncuropeptides on the nervous system. We investigated the structure activity relations (SARs) of peptides derived from adrenecorticotropo hormone (ACrH) on cloned MC3, MC4 and MC5 receptors(More)
Please be advised that this information was generated on 2016-05-01 and may be subject to change. A bstract Previous studies have shown that stressors at­ tenuate LiCl-induced conditioned taste aversions (CTA) but not morphine-induced CTA. The current studies ex­ amined the effects of footshock on the acquisition and extinction of amphetamine-induced CTA.(More)