Mireia Uribe-Herranz

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BACKGROUND TNF and its receptors TNF-Receptor 1 (TNFR1, CD120a) and TNF-Receptor 2 (TNFR2, CD120b) have been implicated in the rejection of transplanted cells and organs. Although pig TNFR1 (pTNFR1) is known to mediate the effects of human TNF in a xenogeneic setting, it is unclear whether pig TNFR2 (pTNFR2) could contribute to xenograft rejection. (More)
Transplantation may be the best option for the repair of many cartilage lesions including early osteoarthritis. Currently, autologous and allogeneic chondrocytes are grafted into cartilage defects to treat selected patients with moderate clinical success. However, their limited use justifies exploring novel therapies for cartilage repair.(More)
Proteins are the focus of numerous xenotransplantation studies because they provide structure and function to the graft. Their presence, absence, or even a functional incompatibility among species can compromise the long-term functioning of the xenograft. In particular, many cell-surface and soluble proteins, such as cytokines and chemokines, are involved(More)
Understanding the molecular bases of xenograft rejection is one of the highest priorities in the xenotransplantation field. Furthermore, the identification of physiological incompatibilities in the xenogeneic setting is also necessary for developing the appropriate strategies to have a long-term functioning xenograft. As the pig is the species of choice for(More)
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