Mireia García

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DNA methylation is a key epigenetic mechanism for driving and stabilizing cell-fate decisions. Local deposition and removal of DNA methylation are tightly coupled with transcription factor binding, although the relationship varies with the specific differentiation process. Conversion of monocytes to osteoclasts is a unique terminal differentiation process(More)
Monocyte-to-osteoclast conversion is a unique terminal differentiation process that is exacerbated in rheumatoid arthritis and bone metastasis. The mechanisms implicated in upregulating osteoclast-specific genes involve transcription factors, epigenetic regulators and microRNAs (miRNAs). It is less well known how downregulation of osteoclast-inappropriate(More)
Lorenzo de la Rica (ldelarica@idibell.org) Javier Rodríguez-Ubreva (jrubreva@idibell.org) Mireia García (mgperez@idibell.org) Abul BMMK Islam This peer-reviewed article can be downloaded, printed and distributed freely for any purposes (see copyright notice below). permits unrestricted use, distribution, and reproduction in any medium, provided the original(More)
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