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Epidemiological studies suggest that the frequent intake of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with a decreased risk of developing esophageal squamous cell carcinoma (SCC). This decrease is thought to correlate with the inhibition of cyclooxygenase (COX) activity. The production of prostaglandin E2 (PGE2), a major metabolite of(More)
Our laboratory has used a rodent model of human esophageal squamous cell carcinoma to identify putative chemopreventive agents for this disease and to determine their mechanisms of action. In the present study, we treated F344 rats with the esophageal carcinogen, N-nitrosomethylbenzylamine (NMBA), thrice per week for 5 weeks. Beginning 1 week later, they(More)
Our laboratory has used a rodent model of human esophageal squamous cell carcinoma to identify putative chemopreven-tive agents for this disease and to determine their mechanisms of action. In the present study, we treated F344 rats with the esophageal carcinogen, N-nitrosomethylbenzylamine (NMBA), thrice per week for 5 weeks. Beginning 1 week later, they(More)
BACKGROUND Aboriginal Australians experience a disproportionately high burden of alcohol-related harm compared to the general Australian population. Alcohol treatment approaches that simultaneously target individuals and families offer considerable potential to reduce these harms if they can be successfully tailored for routine delivery to Aboriginal(More)
PURPOSE To examine the effects of an intensive Smooth Speech therapy technique on the speech production of an individual with ataxic dysarthria and on the individual's level of functioning on the domains of the International Classification of Functioning, Disability and Health (ICF). METHOD This study utilized a single-subject experimental design. One(More)
The importance of early identification of at-risk readers has received attention in recent literature. This paper reviews evidence for oral language components, shown to have predictive capacity to identify at-risk readers at an early age. Both phonological and non-phonological components of oral language difficulties are linked to poor reading outcomes in(More)
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