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Wnt/β-catenin signalling plays essential roles in embryonic development as well as tissue homoeostasis in adults. Thus abnormal regulation of Wnt/β-catenin signalling is linked to a variety of human diseases, including cancer, osteoporosis and Alzheimer's disease. Owing to the importance of Wnt signalling in a wide range of biological fields, a better(More)
Feature-oriented analysis (FOA) provides key information for developing reusable and adaptable product line assets. The information includes commonalities and variabilities, various dependencies between features, and their binding time information. On the other hand, aspect-oriented programming (AOP) provides effective mechanisms for encapsulating(More)
A recent literature on the economics of conflict has provided conditions under which an " anarchic " outcome may come to serve as an equilibrium for an economy, as well as conditions under which a " dictator " or " government agent " is empowered to make collective action choices that enable the economy to achieve a Pareto superior equilibrium. This paper(More)
This paper describes the concept of software adaptation patterns and how they can be used in software adaptation of service-oriented architectures. The patterns are described in terms of a three-layer architecture for self-management. A software adaptation pattern defines how a set of components that make up an architecture pattern dynamically cooperate to(More)
The research field of Intelligent Service Robots, which has become more and more popular over the last years, covers a wide range of applications from climbing machines for cleaning large storefronts to robotic assistance for disabled or elderly people. When developing service robot software, it is a challenging problem to design the robot architecture by(More)
Identifying and representing domain requirements among products in a product family are crucial activities for a successful software reuse. The domain requirements should be not only identified based on the business goal, which drives marketing plan, product plan, and differences among products, but also represented as familiar notations in order to support(More)
The possibility that the degeneration of hippocampal neurons can be caused by mis-regulation of Wnt/β-catenin signaling was tested. Downregulation of Wnt signaling by the inducible expression of Axin, ICAT, and dnTcf4E causes degeneration of hippocampal neurons, while upregulation of Wnt signaling by the inducible expression of Dvl and β-catenin has a(More)
Our aim is to develop the service robot based on a systematic software engineering method, particularly for real-time, embedded and distributed systems with UML. To do so, we applied the COMET method, which is a UML-based method for the development of concurrent applications, specifically distributed and real-time applications. We describe our experience of(More)