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Parathyroid hormone signaling in bone and kidney
TLDR
Recent studies demonstrate the involvement of novel factors as well as additional roles for previously identified downstream factors of PTH, both as a mediator and regulator. Expand
Identification and characterization of Runx2 phosphorylation sites involved in matrix metalloproteinase‐13 promoter activation
TLDR
The Runx2 phosphorylation sites necessary for PKA stimulated MMP‐13 promoter activation are identified and this event may be critical for bone remodeling. Expand
Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion
TLDR
An in vivo assay using transgenic zebrafish with a GFP-marked migrating posterior lateral line primordium (PLLp) to identify compounds that influence collective cell migration is developed and the screen can successfully identify compounds active in vivo and potentially new pathways for targeting cancer metastasis. Expand
A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes
TLDR
This study is the first example of using a systems genetics approach to successfully identify novel susceptibility genes for aggressive prostate cancer using the C57BL/6-Tg(TRAMP)8247Ng/J mouse model. Expand
Runx2 recruits p300 to mediate parathyroid hormone's effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene.
TLDR
The studies suggest that without altering the gross chromatin structure, PTH stimulates acetylation of histones H3 and H4 via recruitment of p300 to Runx2 bound to the MMP-13 promoter, resulting in gene activation. Expand
Parathyroid Hormone Activation of Matrix Metalloproteinase-13 Transcription Requires the Histone Acetyltransferase Activity of p300 and PCAF and p300-dependent Acetylation of PCAF*
TLDR
It is demonstrated that PCAF acts downstream of PTH signaling as a transcriptional coactivator that is required for PTH stimulation of MMP-13 transcription. Expand
Metastasis-Associated Protein Ribosomal RNA Processing 1 Homolog B (RRP1B) Modulates Metastasis through Regulation of Histone Methylation
TLDR
RRP1B, a breast cancer metastasis suppressor, regulates gene expression through heterochromatinization and transcriptional repression, which helps the understanding of mechanisms that drive prognostic gene expression in human breast cancer. Expand
SIN3A and SIN3B differentially regulate breast cancer metastasis
TLDR
Key functional differences between SIN3 paralogs in regulating the process of breast cancer metastasis are demonstrated and suggest metastasis suppressive roles of Sin3A and metastasis promoting roles ofSIN3B. Expand
Necdin is a breast cancer metastasis suppressor that regulates the transcription of c-Myc
TLDR
Haplotype analysis in a well-characterized breast cancer cohort revealed thatNDN germline variation is associated with both NDN expression levels and patient outcome, and ChIP assays demonstrate that NDN and the T50C allele regulate gene expression and metastasis efficiency. Expand
Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer.
TLDR
Crossing a dominant, penetrant mouse model of prostate cancer to Diversity Outbred mice demonstrates how well-characterized genetic variation in mice can be harnessed in conjunction with systems genetics approaches to identify and characterize germline modifiers of human disease processes. Expand
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