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Here, we describe a novel mechanism for the rapid regulation of surface levels of the neurotrophin receptor TrkB. Unlike nodose ganglion neurons, both retinal ganglion cells (RGCs) and spinal motor neurons (SMNs) in culture display only low levels of surface TrkB, though high levels are present intracellularly. Within minutes of depolarization or cAMP(More)
Bloom's Taxonomy is difficult to apply consistently to assessment tasks in introductory programming courses. The Bloom taxonomy is a valuable tool that could enable analysis and discussion of programming assessment if it could be interpreted consistently. We discuss each of the Bloom classification categories and provide a consistent interpretation with(More)
liver-enriched gene 1 (leg1) is a liver-enriched gene in zebrafish and encodes a novel protein. Our preliminary data suggested that Leg1 is probably involved in early liver development. However, no detailed characterization of Leg1 has been reported thus far. We undertook both bioinformatic and experimental approaches to study leg1 gene structure and its(More)
Exogenous nitrogen (N) and sulfate (SO42-), resulting from human activity, can strongly influence the emission of CH4 and CO2 from soil ecosystems. Studies have reported the effects of N and SO42- on CH4 and CO2 emissions from inland peatlands and paddies. However, very few studies have presented year-round data on the effects of the addition of N and SO42-(More)
Neurotrophins transmit signals retrogradely from synapses to cell bodies by two different types of surface receptors, p75NTR and Trks. Compared to TrkA, the function of p75NTR in nerve growth factor (NGF) endocytosis is less clear, and it is unknown whether p75NTR by itself may internalize other neurotrophins besides NGF. We directly compared TrkA and(More)
Conventional molecular imprinting technology allows the synthesis in organic solvents of molecularly imprinted polymers (MIPs) selective toward relatively low molecular weight compounds. However, synthesis in aqueous media of chemically and mechanically stable MIPs that can recognize biomolecules such as peptides and proteins still is a great challenge. In(More)
A novel sorbent for solid-phase extraction (SPE) was synthesized by chemical immobilization of ampholine on hybrid organic-inorganic silica material. The ampholine-functionalized hybrid organic-inorganic silica sorbent is consisted of aliphatic amine groups, carboxyl groups and long carbon chains, allowing for extraction of both acidic and basic compounds.(More)
Introductory programming courses have been continuously reported as having a high rate of failure or withdrawal. This research aims to develop a new approach for teaching novice programming, which is both easy to introduce and effective in improving novice learning. Our approach combines three key ideas: using a visual programming language; using(More)
This paper reports on the combining of two related but hitherto distinct themes in programming education research. The first is the recognition that students in programming courses tend to perform far more poorly than their teachers would like, and further, more poorly than their teachers would expect without a careful analysis of their results. The second(More)