Mingyan Dai

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BACKGROUND Fatty acid (FA) catabolism abnormality has been proved to play an important role in obesity-related cardiomyopathy. We hypothesized that cardiospecific suppression of CD36, the predominant membrane FA transporter, would protect against obesity-related cardiomyopathy. METHODS Four-wk-old male C57BL/6 J mice were fed with either high-fat-diet(More)
This study aimed to investigate the effects of low-level carotid baroreflex stimulation (LL-CBS) on atrial electrophysiology. In protocol 1 (LL-CBS on physiological state), anesthetized rabbits were subjected to LL-CBS (n = 10) or surgical exposure (n = 6) for 1 h. In protocol 2 (LL-CBS on acute rapid atrial pacing), anesthetized rabbits underwent 3 h of(More)
OBJECTIVE To determine whether inhibiting cardiac carnitine palmitoyltransferase-1b (CPT-1b) improves obesity-related cardiomyopathy. METHODS Four-week-old male C57BL/6J mice were fed with high-fat diet (HFD) for 12 weeks to induce obesity. At 6 weeks of age, mice were subjected to intramyocardial injection with lentivirus to down-regulate the expression(More)
BACKGROUND QT hysteresis phenomenon exists in healthy subjects, and is more exaggerated in patients with coronary artery disease (CAD) and long QT syndrome. The purpose of this study was to establish an appropriate method to evaluate the magnitude of QT hysteresis, and assess the value of QT hysteresis index in the treadmill exercise test (TET) in(More)
BACKGROUND Low-level carotid baroreflex stimulation (LL-CBS) appears to have a potential antiarrhythmogenic effect. OBJECTIVE The purpose of this study was to investigate effects of short-term LL-CBS on an atrial fibrillation (AF) canine model. METHODS Group 1 (LL-CBS in the 6 hour-rapid atrial pacing model): Anesthetized dogs underwent 6 hours of rapid(More)
BACKGROUND Cervical cancer is a common gynecologic malignant tumor and has a great impact on women's health. Human papillomavirus (HPV) is implicated in cervical cancer and precancerous lesions and the two are possibly two stages of disease progression. With the technological development of molecular biology and epidemiology, detection and treatment of HPV(More)
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