Mingwei Zhou

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Herein, we describe the pharmacokinetic optimization of a series of class-selective histone deacetylase (HDAC) inhibitors and the subsequent identification of candidate predictive biomarkers of hepatocellular carcinoma (HCC) tumor response for our clinical lead using patient-derived HCC tumor xenograft models. Through a combination of conformational(More)
The characteristics of the environmental settings of the sea area adjacent to the Changjiang River estuary include complex currents and water masses, the diluted water plume and its redirection, upwelling, front, and nutrients and their sources. The Changjiang River estuary characteristics also include the phytoplankton community, which can affect the(More)
Tenix won the ANZAC Ship Contract in November 1989 to build ten guided missile frigates for the navies of Australia and New Zealand. The ships are planned to have a service life of 25 to 30 years. Within this time period, there will be changes in the operational requirements for these vessels. The ANZAC Ship Alliance is a virtual enterprise formed by Tenix(More)
Desktop computers based virtual training systems are attracting paramount attention from manufacturing industries due to their potential advantages over the conventional training practices. Significant cost savings can be realized due to the shorter training-scenarios development times and reuse of existing engineering models. In addition, by using computer(More)
The core competence of a global engineering and manufacturing enterprise increasingly depends on the quality of its intellectual resources and how these resources are used. This paper presents an approach to document-based knowledge management in a typical global engineering and manufacturing application, the ANZAC Ship Project. 1. Document-based Knowledge(More)
Australian coal mines have been facing a major challenge of increasing risk of flooding caused by intensive rainfall events in recent years. In light of growing climate change concerns and the predicted escalation of flooding, estimating flood inundation risk becomes essential for understanding sustainable mine water management in the Australian mining(More)
Described herein are the discovery and structure-activity relationship (SAR) studies of the third-generation 4-H heteroaryldihydropyrimidines (4-H HAPs) featuring the introduction of a C6 carboxyl group as novel HBV capsid inhibitors. This new series of 4-H HAPs showed improved anti-HBV activity and better drug-like properties compared to the first- and(More)