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Distinct domains of Complexin I differentially regulate neurotransmitter release
TLDR
It is shown that distinct functional domains of CplxI differentially regulate synaptic exocytosis and that, through the interplay between these domains, CplXI carries out a crucial role in fine-tuning Ca2+-triggered fast neurotransmitter release. Expand
Drosophila Spastin Regulates Synaptic Microtubule Networks and Is Required for Normal Motor Function
TLDR
Surprisingly, however, in spastin-null mutants, there are fewer microtubule bundles within the NMJ, especially in its distal boutons, which may be relevant to an understanding of human Spastin's role in maintenance of axon terminals in the spinal cord. Expand
GABAergic dysfunction mediates autism-like stereotypies and Rett syndrome phenotypes
TLDR
It is shown that mice lacking Mecp2 from GABA-releasing neurons recapitulate numerous Rett syndrome and autistic features, including repetitive behaviours, and that subtle dysfunction of GABAergic neurons contributes to numerous neuropsychiatric phenotypes. Expand
Structurally and functionally unique complexins at retinal ribbon synapses
TLDR
Two novel vertebrate complexins (CPXs), CPXs III and IV, are identified and characterized that are the only CPX isoforms present in retinal ribbon synapses and may contribute to the unique release efficacy of retinal sensory neurons. Expand
Retrograde Gbb signaling through the Bmp type 2 receptor Wishful Thinking regulates systemic FMRFa expression in Drosophila
TLDR
It is proposed that Wit and Gbb globally regulate NMJ function by controlling both the growth and transmitter release properties of the synapse as well as the expression of systemic modulators of NMJ synaptic activity. Expand
Tilting the Balance between Facilitatory and Inhibitory Functions of Mammalian and Drosophila Complexins Orchestrates Synaptic Vesicle Exocytosis
TLDR
It is found that murine and Drosophila Complexins employ conserved mechanisms to regulate exocytosis despite their strikingly different overall effects on neurotransmitter release, reconciling previous incompatible findings. Expand
Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity
TLDR
It is proposed that the complexin N terminus stabilizes the SNARE complex C terminus and/or helps release the inhibitory function of complexins, thereby activating the fusion machinery in a manner that may cooperate with Syt1 but does not require Syt 1. Expand
The Janus-Faced Nature of the C2B Domain Is Fundamental for Synaptotagmin-1 Function
TLDR
It is shown that mutating two conserved arginine residues at the C2B domain bottom face practically abolishes synchronous release in hippocampal neurons and strongly support the notion that synaptotagmin-1 triggers membrane fusion and neurotransmitter release by bringing the vesicle and plasma membranes together, much like the SNAREs do but in a Ca2+-dependent manner. Expand
Structural and Mutational Analysis of Functional Differentiation between Synaptotagmins-1 and -7
TLDR
The results suggest that functional differentiation in synaptotagmin-1 knockout mice arises in part from subtle sequence changes that yield dramatic functional differences. Expand
Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system
TLDR
It is shown that genetic deletion of all Cplxs expressed in the mouse brain causes a reduction in Ca2+-triggered and spontaneous neurotransmitter release at both excitatory and inhibitory synapses. Expand
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