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Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel.
A novel anti-cancer PDC engineered with side groups of disulfide and ester bonds for on-demand delivery of paclitaxel (PTX) with redox and pH dual sensitive behaviors provides a useful strategy for anti-tumor drug delivery. Expand
Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer.
In vitro cytotoxicity assays against A549 human lung adenocarcinoma cell line demonstrated that the DOX + PTX co-delivered nanoparticles (Co-NPs) exhibited synergistic effect in inducing cancer cell apoptosis, indicating this co- delivery system with different functional antitumor drugs provides the clinical potential in cancer therapy. Expand
Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide
It is demonstrated that P-HNPs delivering Cas9 plasmid/sgRNA targeting the polo-like kinase 1 (Plk1) gene achieved 35% gene deletion in HeLa tumor tissue to reduce the Plk1 protein level by 66.7%, thereby suppressing the tumor growth by >71% and prolonging the animal survival rate to 60% within 60 days. Expand
Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efficient drug delivery system for cancer therapy.
In vivo studies on the subcutaneous non-small cell lung cancer (A549) xenograft nude mice model confirmed that DOX-NP showed significant antitumor activity and reduced side effects, and then enhanced tumor accumulation as a result of the prolonged circulation in blood and the enhanced permeation and retention effect, indicating its great potential for cancer therapy. Expand
Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery of doxorubicin.
These cisplatin prodrug crosslinked polysaccharide nanoparticles proved to be a promising nanomedicine drug delivery system for tumor-targeted delivery of DOX and exhibited enhanced therapeutic efficacy in tumor-bearing mice. Expand
CRISPR/Cas9-Based Genome Editing for Disease Modeling and Therapy: Challenges and Opportunities for Nonviral Delivery.
The rapidly developing CRISPR/Cas9-based technologies for disease modeling and gene correction and recent progress toward Cas9/guide RNA (gRNA) delivery based on viral and nonviral vectors are reviewed. Expand
Engineered nanomedicines with enhanced tumor penetration
Abstract Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is inefficientExpand
Polypeptide-based combination of paclitaxel and cisplatin for enhanced chemotherapy efficacy and reduced side-effects.
The polypeptide-based combination of PTX and CDDP may provide useful guidance for effective and safe cancer chemotherapy. Expand
Cell-laden microfluidic microgels for tissue regeneration.
This review examines microfluidics-generated cell-laden microgels for tissue regeneration applications and provides a brief overview of the common biomaterials, gelation mechanisms, andmicrofluidic device designs that are used to generate these microGels. Expand
Nanoscaled poly(L-glutamic acid)/doxorubicin-amphiphile complex as pH-responsive drug delivery system for effective treatment of nonsmall cell lung cancer.
The results demonstrated that mPEG-b-PLG was a promising vector to deliver DOX·HCl into tumors and achieve improved pharmacokinetics, biodistribution and efficacy of DOX-HCl with reduced toxicity. Expand