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Controllable gene expression is always a challenge and of great significance to biomedical research and clinical applications. Recently, various approaches based on extra-engineered light-sensitive proteins have been developed to provide optogenetic actuators for gene expression. Complicated biomedical techniques including exogenous genes engineering,(More)
In this paper we explore the existence of electromagnetic surface bound modes on a perfect metal wire milled with arrays of subwavelength grooves. The surface modes are axially symmetric transverse magnetic (TM) waves and have the same polarization state with the dominant propagating surface plasmon polaritons on the real metal wires. The dispersion of the(More)
We reported a dual-wavelength femtosecond optical parametric oscillator (OPO) based on a temperature-tuned LiB₃O₅ crystal. The OPO was synchronously pumped by a frequency-doubled, mode-locked Yb-fiber laser amplifier, providing a 520 nm pump laser with durations of 250 fs at a repetition rate of 57 MHz. High efficiency and dual-wavelength operation are(More)
The cross correlation between a pair of femtosecond lasers with slightly different repetition rates enables high precision, high update rate time-of-flight (TOF) distance measurements against multiple targets. Here, we investigate the obtainable ranging precision set by the timing jitter from femtosecond lasers. An analytical model governing dual(More)
The use of nanojoule femtosecond pulses (NFP) for highly precise proceeding in anti-glaucoma surgery was evaluated. According to the observation of scanning electron microscopy (SEM), four types of incision patterns, including subsurface, slit-like, spot and cuboid ablations, were accomplished on in vitro sclera by NFP with little collateral damage. In(More)
Irradiation of crystalline silicon with femtosecond laser pulses produces a variety of quasi-periodic surface structures, among which sub-wavelength ripples creation is largely studied. Here we report an experimental investigation and a theoretical interpretation focusing on the seldom considered issue of quasi-periodic, micron spaced grooves formation. We(More)
We characterize the timing jitter of a picosecond all-polarization-maintaining (all-PM) Yb-fiber laser using the optical cross-correlation method. For the 10 MHz all-normal dispersion mode-locked laser with ~0.5 nm spectral bandwidth, the measured high-frequency jitter is as low as 5.9 fs (RMS) when integrated from 10 kHz to the Nyquist frequency of 5 MHz.(More)
Mitochondria play a key role in all cellular physiology, processes, and behaviors. It is very difficult to precisely stimulate single mitochondria noninvasively in traditional biomedical research. In this study, we report that femtosecond laser can stimulate fragmentation or swelling of single mitochondria in human mesenchymal stem cells rather than(More)
The theory of guided waves in metal-dielectric planar multilayer structures is applied to reduce the loss and maximize optical nonlinearity for efficient terahertz-field generation in a surface electromagnetic wave by femtosecond laser pulses confined in a (chi)((2)) nonlinear planar waveguide. For typical parameters of thin-film polymer waveguides and(More)
We report on a nonlinear preshaper that optimizes initial pulses for self-similar evolution in a next fiber amplifier. It consists of a pair of gratings and a segment of single-mode fiber (SMF). The grating pair provides negative chirp to make the pulses preshaped temporally and spectrally in the SMF. With this optimization, the self-similar amplification(More)