Minglie Hu

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Controllable gene expression is always a challenge and of great significance to biomedical research and clinical applications. Recently, various approaches based on extra-engineered light-sensitive proteins have been developed to provide optogenetic actuators for gene expression. Complicated biomedical techniques including exogenous genes engineering,(More)
In this paper we explore the existence of electromagnetic surface bound modes on a perfect metal wire milled with arrays of subwavelength grooves. The surface modes are axially symmetric transverse magnetic (TM) waves and have the same polarization state with the dominant propagating surface plasmon polaritons on the real metal wires. The dispersion of the(More)
Nonlinearity of semiconductor nanowires makes them potential frequency converters in nanoscale optoelectronics. Here we demonstrate that sum frequency generation signals can be acquired from GaAs nanowires when excited by a femtosecond laser at 1048 nm and a tunable optical parametric oscillator ranging from 1416 nm to 1770 nm. The SFG intensity is(More)
The cross correlation between a pair of femtosecond lasers with slightly different repetition rates enables high precision, high update rate time-of-flight (TOF) distance measurements against multiple targets. Here, we investigate the obtainable ranging precision set by the timing jitter from femtosecond lasers. An analytical model governing dual(More)
The use of nanojoule femtosecond pulses (NFP) for highly precise proceeding in anti-glaucoma surgery was evaluated. According to the observation of scanning electron microscopy (SEM), four types of incision patterns, including subsurface, slit-like, spot and cuboid ablations, were accomplished on in vitro sclera by NFP with little collateral damage. In(More)
Irradiation of crystalline silicon with femtosecond laser pulses produces a variety of quasi-periodic surface structures, among which sub-wavelength ripples creation is largely studied. Here we report an experimental investigation and a theoretical interpretation focusing on the seldom considered issue of quasi-periodic, micron spaced grooves formation. We(More)
We characterize the timing jitter of a picosecond all-polarization-maintaining (all-PM) Yb-fiber laser using the optical cross-correlation method. For the 10 MHz all-normal dispersion mode-locked laser with ~0.5 nm spectral bandwidth, the measured high-frequency jitter is as low as 5.9 fs (RMS) when integrated from 10 kHz to the Nyquist frequency of 5 MHz.(More)
Mitochondria play a key role in all cellular physiology, processes, and behaviors. It is very difficult to precisely stimulate single mitochondria noninvasively in traditional biomedical research. In this study, we report that femtosecond laser can stimulate fragmentation or swelling of single mitochondria in human mesenchymal stem cells rather than(More)
Photonic-crystal fibers (PCFs) are widely recognized as efficient sources of white-light supercontinuum. Here, we show that a combination of an ultrashort-pulse ytterbium PCF laser with a highly nonlinear PCF enables all-fiber generation of ultrashort pulses of coherent UV radiation in the black-light spectral region with all the key processes, such as(More)
We report on the highly efficient generation of widely tunable femtosecond pulses based on intracavity second harmonic generation (SHG) and sum frequency generation (SFG) in a MgO-doped periodically poled LiNbO(3) optical parametric oscillator (OPO), which is pumped by a Yb-doped large-mode-area photonics crystal fiber femtosecond laser. Red and near(More)