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BACKGROUND & AIMS Directed migration of hepatic myofibroblasts (hMFs) contributes to the development of liver fibrosis. However, the signals regulating the motility of these cells are incompletely understood. We have recently shown that sphingosine 1-phosphate (S1P) and S1P receptors (S1PRs) are involved in mouse liver fibrogenesis. Here, we investigated(More)
In this paper we prove a conjecture on a common region of a convergence of Padé iterations for the matrix sector function. For this purpose we show that all Padé approximants to a special case of hypergeometric function have a power series expansion with positive coefficients. Using a sharpened version of Schwarz’s lemma, we also demonstrate a better(More)
ASPP2 is a pro-apoptotic member of the p53 binding protein family. ASPP2 has been shown to inhibit autophagy, which maintains energy balance in nutritional deprivation. We attempted to identify the role of ASPP2 in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In a NAFLD cell model, control treated and untreated HepG2 cells were(More)
Wilson's disease (WD) is a rare disorder of copper metabolism resulting in accumulation of copper in liver and other organs. We present a liver failure patient, who was misdiagnosed for two years, with normal ceruloplasmin and low serum alkaline phosphatase. Molecular testing revealed a novel p.Ala982Thr mutation within ATP7B gene. The pathology of liver(More)
A new notion of coneigenvalue was introduced by Ikramov in [On pseudo-eigenvalues and singular numbers of a complex square matrix, (in Russian), Zap. Nauchn. Semin. POMI 334 (2006), 111-120]. This paper presents some majorization inequalities for coneigenvalues, which extend some classical majorization relations for eigenvalues and singular values, and may(More)