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BACKGROUND & AIMS Directed migration of hepatic myofibroblasts (hMFs) contributes to the development of liver fibrosis. However, the signals regulating the motility of these cells are incompletely understood. We have recently shown that sphingosine 1-phosphate (S1P) and S1P receptors (S1PRs) are involved in mouse liver fibrogenesis. Here, we investigated… (More)
An identity involving binomial coefficients that appeared in the evaluation of a definite integral is established by a variety of methods.
Wilson's disease (WD) is a rare disorder of copper metabolism resulting in accumulation of copper in liver and other organs. We present a liver failure patient, who was misdiagnosed for two years, with normal ceruloplasmin and low serum alkaline phosphatase. Molecular testing revealed a novel p.Ala982Thr mutation within ATP7B gene. The pathology of liver… (More)
ASPP2 is a pro-apoptotic member of the p53 binding protein family. ASPP2 has been shown to inhibit autophagy, which maintains energy balance in nutritional deprivation. We attempted to identify the role of ASPP2 in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In a NAFLD cell model, control treated and untreated HepG2 cells were… (More)
Let H = M K K * N be a Hermitian matrix. It is known that the vector of diagonal elements of H, diag(H), is majorized by the vector of the eigenvalues of H, λ(H), and that this majorization can be extended to the eigenvalues of diagonal blocks of H. Reverse majorization results for the eigenvalues are our goal. Under the additional assumptions that H is… (More)
Let A,B,C be n× n positive semidefinite matrices. It is known that det(A+ B + C) + detC ≥ det(A+ C) + det(B + C), which includes det(A+B) ≥ detA+ detB as a special case. In this article, a relation between these two inequalities is proved, namely, det(A+ B + C) + detC − (det(A+ C) + det(B + C)) ≥ det(A+ B)− (detA+ detB).
A new notion of coneigenvalue was introduced by Ikramov in [On pseudo-eigenvalues and singular numbers of a complex square matrix, This paper presents some majorization inequalities for coneigenvalues, which extend some classical majorization relations for eigenvalues and singular values, and may serve as a basis for further investigations in this area.