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Biosynthesis of himastatin: assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps.
Halogenated anthraquinones from the marine-derived fungus Aspergillus sp. SCSIO F063.
Metabolomic investigations focusing on the marine-derived fungus Aspergillus sp. SCSIO F063 have unveiled seven new chlorinated anthraquinones (1-7) related to averantin, together with five known… Expand
Identification of the grincamycin gene cluster unveils divergent roles for GcnQ in different hosts, tailoring the L-rhodinose moiety.
The gene cluster responsible for grincamycin (GCN, 1) biosynthesis in Streptomyces lusitanus SCSIO LR32 was identified; heterologous expression of the GCN cluster in S. coelicolor M512 yielded… Expand
Discovery and Engineered Overproduction of Antimicrobial Nucleoside Antibiotic A201A from the Deep-Sea Marine Actinomycete Marinactinospora thermotolerans SCSIO 00652
- Qinghua Zhu, J. Li, +8 authors J. Ju
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 7 November 2011
ABSTRACT Marinactinospora thermotolerans SCSIO 00652, originating from a deep-sea marine sediment of the South China Sea, was discovered to produce antimicrobial nucleoside antibiotic A201A.… Expand
Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation.
9-Methylstreptimidone is a glutarimide antibiotic showing antiviral, antifungal, and antitumor activities. Genome scanning, bioinformatics analysis, and gene inactivation experiments reveal a gene… Expand
Circulating Tumor Cells: From Theory to Nanotechnology-Based Detection
Cancer stem cells with stem-cell properties are regarded as tumor initiating cells. Sharing stem-cell properties, circulating tumor cells (CTCs) are responsible for the development of metastasis,… Expand
Specific cancer stem cell-therapy by albumin nanoparticles functionalized with CD44-mediated targeting
- Y. Li, Sanjun Shi, +6 authors Jian-hong Chen
- Medicine, Biology
- Journal of Nanobiotechnology
- 1 December 2018
BackgroundCancer stem cells (CSCs) are highly proliferative and tumorigenic, which contributes to chemotherapy resistance and tumor occurrence. CSCs specific therapy may achieve excellent therapeutic… Expand
Cytochalasan and Tyrosine-Derived Alkaloids from the Marine Sediment-Derived Fungus Westerdykella dispersa and Their Bioactivities
Six new cytochalasans, designated as 18-oxo-19,20-dihydrophomacin C (1), 18-oxo-19-methoxy-19,20- dihydrophomacin C (2), 18-oxo-19-hydroxyl-19,20-dihydrophomacin C (3), 19,20-dihydrophomacin C (4),… Expand
A mycophenolic acid derivative from the fungus Penicillium sp. SCSIO sof101
Abstract Mycophenolic acid (MPA) is a group of metabolite derived from several species of Penicillium, which shows potent bioactivity. In this study, a new derivative of MPA compound named penicacid… Expand
Observation of the lithium storage behavior in LiCrTiO4 via in-situ and ex-situ techniques
Abstract Spinel LiCrTiO 4 is synthesized via sol-gel pretreatment and subsequent solid state reaction at different calcining temperatures. Structural observation and electrochemical evaluation show… Expand