Minghao Li

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Alterations in tetraspanin CO-029 expression are associated with the progression and metastasis of cancers in the digestive system. However, how CO-029 promotes cancer metastasis is still poorly understood. To determine the mechanism, we silenced CO-029 expression in HT29 colon cancer cells and found that the CO-029 knockdown significantly reduced cell(More)
In this study , torque loading tests on small shear blocks were performed to evaluate the rolling shear strength of cross-laminated timber (CLT). The CLT plates in the tests were manufactured with Mountain Pine Beetle-afflicted lumber boards and glued with polyurethane adhesive; two types of layups (five-layer and three-layer) with a clamping pressure 0.4(More)
BACKGROUND The constitutive hyper-activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways has frequently been associated with acute myeloid leukemia (AML). While many inhibitors targeting these pathways have been developed, the anti-leukemic effect was not as robust as expected. As(More)
BACKGROUND Though accumulated evidence proved the advantages of laparoscopic hepatectomy, bleeding still remains the most important challenge in clinical practice. Our study aimed to compare the outcomes of Pringle maneuver (PM) and selective hemihepatic vascular occlusion (SHVO) surgeries for patients with liver cavernous hemangioma (LCH). METHODS The(More)
This paper presents a structural model called “PB3D” to perform nonlinear time history analyses of post and beam timber buildings under seismic loads. The model treats the three-dimensional structure as an assembly of roof/floor diaphragms and wall subsystems. The roof/floor diaphragms are modeled by beam elements and diagonal brace elements in order to(More)
This paper presents an approach to evaluate the performance reliability of post-and-beam timber buildings under seismic excitation. The uncertainties considered include those associated with the earthquake ground motions, the structural mass and shear wall characteristics. The approach uses a verified structural model called “PB3D” for the creation of a(More)