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Although the molecular mechanism is not clear, the clinically tested drug ketamine has rapid antidepressant action that does not require the multiple weeks of treatment needed for other antidepressant drugs to have an effect. We showed that ketamine potentiated Schaffer collateral-CA1 cell excitatory synaptic transmission in hippocampal slice preparations(More)
Exposure to early stressful adverse life events such as maternal separation severely impacts the development of the nervous system. Using immunohistochemistry, quantitative PCR and Western blot approaches, we found that alpha6 subunit-containing GABAA receptors (Gabra6-containing GABAA Rs) were expressed on hippocampal interneurons of adolescent rats.(More)
Ketamine, a noncompetitive NMDA receptor antagonist, exhibits a rapid antidepressant effect, but the underlying mechanism remains obscure. Ketamine and imipramine, a tricyclic antidepressant, share the same targets on AMPA receptors and CREB, whereas ketamine exerts fast-actioning responses compared to traditional antidepressants' slow onset. To figure out(More)
Sex differences in spatial memory have long been observed in humans, non-human primates and rodents, but the underlying cellular and molecular mechanisms responsible for these differences remain obscure. In the present study we found that adolescent male rats outperformed female rats in 7 d and 28 d retention probes, but not in learning trials and immediate(More)
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