Mingbo Qu

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Insect β-N-acetyl-D-hexosaminidases with broad substrate-spectrum (IBS-Hex) are the homologues of human β-N-acetyl-D-hexosaminidase A/B (HsHex A/ B). These enzymes are distributed in most insect species and vary in physiological roles. In this study, the gene encoding an IBS-Hex, OfHEX2, was cloned from the Asian corn borer, Ostrinia furnacalis. Recombinant(More)
Insects require molting fluids to shed the old cuticle during molting. β-N-acetyl-D-hexosaminidase, known as Hex1, together with various chitinases, is responsible for degrading the chitin component of the old cuticle. This study showed that another β-N-acetyl-D-hexosaminidase, termed OfHex3, interacted with Hex1 and functioned in the molting fluid,(More)
We have designed and synthesized novel intercalating compounds that efficiently hydrolyze supercoiled plasmid DNA lacking depurine/depyrimidine sites. These intercalators consist of conjugates of diamine and thia-heterocyclic naphthalimide. Surprisingly, the initial hydrolyzed products comprised fragments with half the length of the original plasmid. We(More)
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