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The SDF-1/CXCR4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute pancreatitis
TLDR
The results demonstrated that the expression of SDF-1 was significantly increased in the injured pancreas, and that these levels peaked on days 5–7 and began to decrease on day 10, which indicates that the interaction of locally produced S DF-1 with CXCR4 on B MSCs, has an important regulatory role in the migration of BMSCs towards the injured pancreatitis in AP.
Comparison of different methods for the isolation of mesenchymal stem cells from umbilical cord matrix: Proliferation and multilineage differentiation as compared to mesenchymal stem cells from
TLDR
It is proposed that UC be considered an alternative to BM and UCB as a source of MSCs for cell therapy and has higher proliferative capacity, higher rate of chondrogenic differentiation, and higher expression of CD 146.
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
TLDR
RAB1A siRNA transfected breast cancer cells suggested that RAB1A acts as an oncogene by regulating cellular proliferation, growth, invasion and metastasis via activation of mTORC1 pathway in triple-negative breast cancer.
JAK2 inhibitor combined with DC-activated AFP-specific T-cells enhances antitumor function in a Fas/FasL signal-independent pathway
TLDR
Results indicate a Fas/FasL-independent pathway for cellular apoptosis in cancer therapies with the treatment of AFP-specific CD8+ T-cells combined with JAK2 inhibitor.
O-GlcNAcylation of YY1 stimulates tumorigenesis in colorectal cancer cells by targeting SLC22A15 and AANAT.
TLDR
It is concluded that O-GlcNAcylation of YY1 stimulates tumorigenesis in CRC cells by targeting SLC22A15 and AANAT, suggesting that YY 1 O- Glc NAcylation might be a potential effective therapeutic target for treating CRC.
Functional Polymorphisms in the CYP2C19 Gene Contribute to Digestive System Cancer Risk: Evidence from 11,042 Subjects
TLDR
The meta-analysis suggested that the PM phenotype caused by the variation on CYP2C19 gene is associated with increased risk of digestive system cancer, especially in East Asians.
Effect of interferon-γ on NF-κB and cytokine IL-18 and IL-27 in acute pancreatitis.
TLDR
To control the IFN-γ might has promise to attenuate pancreatitis, the increase in NF-κB and IL-18 may exert influence on pro-inflammatory cytokines to deteriorate inflammation in the pancreas.
Expression of NOD2 in a Rat Model of Acute Pancreatitis
TLDR
The NOD2 may play an important role in the up-regulation and activation of NF-&kgr;B during inflammation reactions in AP.
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