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BIIR 561 CL is a novel blocker of AMPA receptors and voltage-dependent sodium channels. In this study we further describe the effects of BIIR 561 CL on AMPA receptor-mediated membrane currents in rodent neurons, as well as in cells expressing recombinant human GluR1/2 receptors in more detail. BIIR 561 CL suppressed responses to kainate in neuronal cultures(More)
with dextran sulfate sodium. PKD2 SSAA-knockin mice displayed catalytic activity deficiency and increased susceptibility to DSS-induced colitis with enhanced weight loss, colonic inflammation compared with PKD2 WT/WT mice. Furthermore, crucial inflammatory cytokines mRNA levels in PKD2 SSAA-knockin mice were higher than controls accompanied with(More)
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