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FE65 is expressed predominantly in the brain and interacts with the C-terminal domain of beta-amyloid precursor protein (APP). We examined hippocampus-dependent memory and in vivo long-term potentiation (LTP) at the CA1 synapses with isoform-specific FE65 knockout (p97FE65(-/-)) mice. When examined using the Morris water maze, p97FE65(-/-) mice were(More)
Ca-stimulated adenylyl cyclases (ACs) transduce neuronal stimulation-evoked increase in calcium to the production of cAMP, which impinges on the regulation of many aspects of neuronal function. Type 1 and type 8 AC (AC1 and AC8) are the only ACs that are directly stimulated by Ca. Although AC1 function was implicated in regulating reference spatial memory,(More)
The objective of this study was to assess the effects of whole-body vibration (WBV) on lumbar muscle oxygenation oscillations in healthy men based on the wavelet transform of near-infrared spectroscopy signals. Twelve healthy participants were exposed to WBV at frequencies of 3, 4.5 and 6 Hz while muscle oxygenation signal was monitored before, during and(More)
This paper reports findings of experiments aiming to (1) compare the load tolerant ability over different regions of stumps of lower limb amputees, (2) study the effect of walking on the load tolerant ability, and (3) examine the distal-end weight-bearing ability supported by different interface materials. The method was to apply increasing load to the(More)
Monolimb refers to a kind of transtibial prostheses having the socket and shank molded into one piece of thermoplastic material. One of its characteristics is that the shank is made of a material that can deform during walking, which can simulate ankle joint motion to some extent. Changes in shank geometry can alter the stress distribution within the(More)
Trans-tibial amputees are advised to walk as much as able people to achieve healthy and independent life. However, they usually have difficulties in doing so. Previous researches only included data from a few steps when studying the gait of amputees. Walking over a long distance was rarely examined. The objective of this study was to investigate the changes(More)
Precise quantification of femur strength and accurate assessment of hip fracture risk would help physicians to identify individuals with high risk and encourage them to take preventive interventions. A major contributing factor of hip fracture is the reduction of hip strength, determined by the bone quality. Bone mineral density (BMD) alone cannot determine(More)
When certain memory becomes obsolete, effective suppression of the previously established memory is essential for animals to adapt to the changing environment. At the cellular level, reversal of synaptic potentiation may be important for neurons to acquire new information and to prevent synaptic saturation. Here, we investigated the function of(More)
AIM To characterize the expression and function of midkine (MK) in an in vitro embryonic stem cell (ESC) culture system. METHODS To investigate the potential roles of MK, the expression of MK in ESCs was evaluated by RT-PCR and immunocytochemistry. The effects of MK on the self-renewal of ESCs were measured using alkaline phosphatase assays,(More)
BACKGROUND It has long been proposed that early embryos and reproductive organs exhibit similar gene expression profiles. However, whether this similarity is propagated to the protein level remains largely unknown. We have previously characterised the promiscuous expression pattern of cell surface proteins on mouse embryonic stem (mES) cells. As cell(More)