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Synaptic Defects in the Spinal and Neuromuscular Circuitry in a Mouse Model of Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is a major genetic cause of death in childhood characterized by marked muscle weakness. To investigate mechanisms underlying motor impairment in SMA, we examined theExpand
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Characterization of behavioral and neuromuscular junction phenotypes in a novel allelic series of SMA mouse models.
A number of mouse models for spinal muscular atrophy (SMA) have been genetically engineered to recapitulate the severity of human SMA by using a targeted null mutation at the mouse Smn1 locus coupledExpand
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  • Open Access
The DcpS inhibitor RG3039 improves motor function in SMA mice.
Spinal muscular atrophy (SMA) is caused by mutations of the survival motor neuron 1 (SMN1) gene, retention of the survival motor neuron 2 (SMN2) gene and insufficient expression of full-lengthExpand
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  • Open Access
BAT AGN Spectroscopic Survey. VIII. Type 1 AGN with Massive Absorbing Columns
We explore the relationship between X-ray absorption and optical obscuration within the BAT AGN Spectroscopic Survey (BASS), which has been collecting and analyzing the optical and X-ray spectra forExpand
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Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems
•  Knockout (KO) of complexin in mouse neuromuscular junctions (NMJs) and adrenal chromaffin cells causes a reduction and a loss in synchronicity in calcium‐mediated exocytosis. •  A train ofExpand
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Assessing characteristics of RNA amplification methods for single cell RNA sequencing
BackgroundRecently, measurement of RNA at single cell resolution has yielded surprising insights. Methods for single-cell RNA sequencing (scRNA-seq) have received considerable attention, but theExpand
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Investigating contactless high frequency ultrasound microbeam stimulation for determination of invasion potential of breast cancer cells
In this article, we investigate the application of contactless high frequency ultrasound microbeam stimulation (HFUMS) for determining the invasion potential of breast cancer cells. In breast cancerExpand
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Edge Computing Gateway of the Industrial Internet of Things Using Multiple Collaborative Microcontrollers
An Internet of Things gateway serves as a key intermediary between numerous smart things and their corresponding cloud networking servers. A typical conventional gateway system uses a high-levelExpand
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Chromosomal integration of a synthetic expression control sequence achieves poly‐γ‐glutamate production in a Bacillus subtilis strain
Poly‐γ‐glutamate (γ‐PGA) has applications in food, medical, cosmetic, animal feed, and wastewater industries. Bacillus subtilis DB430, which possesses the γ‐PGA synthesis ywsC‐ywtAB genes in itsExpand
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Flexible ZnO transparent thin-film transistors by a solution-based process at various solution concentrations
We report solution-processed ZnO thin-film transistors (TFTs) on a flexible substrate, using polymethylmethacrylate (PMMA) as a dielectric layer. To improve the compatibility between the ZnO activeExpand
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  • Open Access