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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
TLDR
A set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes are presented.
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The emerging role of microRNAs and long noncoding RNAs in drug resistance of hepatocellular carcinoma
TLDR
Accumulated evidences demonstrate that several deregulated miRNAs and lncRNAs are important regulators in the development of HCC drug resistance which elucidates their potential clinical implications.
View on Springer
Onco-lncRNA HOTAIR and its functional genetic variants in papillary thyroid carcinoma
TLDR
The results demonstrate that functional SNPs influencing lncRNA regulation may explain a part of PTC genetic basis.
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Exome Array Analysis Identifies Variants in SPOCD1 and BTN3A2 That Affect Risk for Gastric Cancer.
TLDR
Exome array analysis of DNA in blood samples from 1113 patients with gastric cancer, collected at hospitals from 2006 to 2010 in China, and 1848 individuals without cancer (controls) undergoing physical examinations indicates a role for SPOCD1 and BTN3A2 in gastric carcinogenesis.
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The long noncoding RNA PCAT-1 links the microRNA miR-215 to oncogene CRKL-mediated signaling in hepatocellular carcinoma
TLDR
It is proposed that the TP53–miR-215–PCAT-1–CRKL axis might represent an important regulatory pathway in HCC and provide critical insights into the molecular pathways operating in this malignancy.
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Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study.
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Integrative Functional Genomics Implicates EPB41 Dysregulation in Hepatocellular Carcinoma Risk.
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N6-methyladenosine reader YTHDC2 and eraser FTO may determine hepatocellular carcinoma prognoses after transarterial chemoembolization.
TLDR
The data implicated that m6A-regulating genes may be targets to improve therapeutic strategy for unresectable HCC patients and reported the first evidence supporting the prognostic value of m5-methyladenosine reader YTHDC2 andm6A eraser FTO SNPs in TACE-treated H CC patients.
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Noncoding RNAs in gastric cancer: implications for drug resistance
TLDR
The emerging role and detailed molecular mechanisms of ncRNAs impact drug resistance of gastric cancer are summarized and the potential clinical implications of n cRNAs as novel therapeutic targets and prognostic biomarkers for gastriccancer are proposed.
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The emerging role of noncoding RNAs in colorectal cancer chemoresistance
TLDR
Tumor-specific miRNAs and lncRNAs may serve as novel therapeutic targets and prognostic biomarkers for CRC and play pivotal roles in the development of chemoresistance.
View on Springer
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