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Human immunodeficiency virus type 1 (HIV-1) infection in mononuclear phagocyte lineage cells (monocytes, macrophages, and microglia) is a critical component in the pathogenesis of viral infection. Viral replication in macrophages serves as a reservoir, a site of dissemination, and an instigator for neurological sequelae during HIV-1 disease. Recent studies(More)
Inflammatory mediators have been implicated in the pathophysiology of neurodegenerative diseases. Here we report the presence of the chemokine receptor CXCR3 and its ligand, IP-10, in normal and Alzheimer's disease (AD) brains. CXCR3 was detected constitutively on neurons and neuronal processes in various cortical and subcortical regions; IP-10 was observed(More)
—Since the Internet consumes a large (and increasing) amount of energy, " green " strategies are desirable to help service providers (SP) operate their networks and provision services more energy efficiently. We focus on green provisioning strategies for optical wavelength-division multiplexing networks. A number of approaches from component layer to(More)
BACKGROUND Invasion and metastasis remain a critical issue in cervical cancer. However, the underlying mechanism of it in cervical cancer remains unclear. The newly discovered protein, TBLR1, plays a crucial role in regulating various key cellular functions. METHODS In this study, western blot, real-time RT-PCR, immunohistochemical staining, 3D(More)
  • Y Li, D Yu, +5 authors M Xia
  • 1993
This study collected records of 245 cases of death due to advanced schistosomiasis japonica in the eastern Dongting Lake area between 1985 and 1990. The mean survival of the patients was 5.16 years. The patients with ascitic type had a shorter expected life while the life span of splenomegalic type patient markedly improved after splenectomy. The HBsAg(More)
CTF7 is an essential gene in yeast that is required for the formation of sister chromatid cohesion. While recent studies have provided insights into how sister chromatid cohesion is established, less is known about how specifically CTF7 facilitates the formation of cohesion, and essentially nothing is known about how sister chromatid cohesion is established(More)
UNLABELLED Noroviruses (NoVs) are the leading cause of nonbacterial acute gastroenteritis worldwide in people of all ages. The P particle is a novel vaccine candidate derived from the protruding (P) domain of the NoV VP1 capsid protein. This study utilized the neonatal gnotobiotic pig model to evaluate the protective efficacies of primary infection, P(More)
BACKGROUND Previously a disease of the West and rarely seen in China, inflammatory bowel disease (IBD) is now increasing in incidence in China. However, its true incidence is unknown. The incidence of IBD in Wuhan, a major city in central China, was investigated using population-based methods. METHODS A prospective, population-based IBD incidence study(More)
Noroviruses, an important cause of acute gastroenteritis in humans, recognize the histo-blood group antigens (HBGAs) as host susceptible factors in a strain-specific manner. The crystal structures of the HBGA-binding interfaces of two A/B/H-binding noroviruses, the prototype Norwalk virus (GI.1) and a predominant GII.4 strain (VA387), have been elucidated.(More)