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OBJECTIVES This prospective, randomized trial compared the safety and effectiveness of laparoscopic Roux-en-Y gastric bypass (LRYGBP) and laparoscopic mini-gastric bypass (LMGBP) in the treatment of morbid obesity. SUMMARY BACKGROUND DATA LRYGBP has been the gold standard for the treatment of morbid obesity. While LMGBP has been reported to be a simple(More)
BACKGROUND Laparoscopic gastric bypass resulted in significant weight loss and resolution of type 2 diabetes mellitus (T2DM). The current indication for bariatric surgery is mainly applied for patients with body mass index (BMI)>35 kg/m2 with comorbidity status. However, little is known concerning T2DM patients with BMI<35 kg/m2. Recent studies have(More)
BACKGROUND Survivin is a potential therapeutic target for cancer. Increased survivin expression promotes cell survival and therapeutic resistance. However, there is little information regarding whether the expression level of survivin affects curcumin treatment in hepatocellular carcinoma (HCC). METHODS Survivin expression was suppressed in HCC cells(More)
BACKGROUND The laparoscopic mini-gastric bypass (MGB) is a modification of Mason's loop gastric bypass, but with a long lesser curvature tube. With weight loss results similar to laparoscopic Roux-en-Y gastric bypass (LRYGBP), the MGB is a simpler operation with a low complication rate. Controversy exists concerning the efficacy and side-effects of this(More)
BACKGROUND Vertical banded gastroplasty (VBG) and gastric bypass (GBP) are the two bariatric procedures recommended by NIH consensus conference. Recent advancement in laparoscopic (L) techniques has made LVBG and LGBP alternatives for the conventional open approach. METHODS From December 2000 to February 2002, 80 patients (24 men and 56 women; mean age 32(More)
BACKGROUND We used 4-year nationwide population-based data to explore the volume-outcome relationships for lung cancer resections in Taiwan and to determine whether there is any association between high-volume hospitals or high-volume surgeons and lower in-hospital mortality rates. METHODS We use pooled data for the years 2001 through 2004 obtained from(More)
BACKGROUND Glucose-regulated protein 78 (GRP78) plays an important role in embryonic development and cancer progression. However, there is little information regarding the regulation of GRP78 in hepatocellular carcinoma (HCC) metastasis. METHODS We used RNA silencing and cDNA expression vectors to manipulate target gene expression in HCC cells. The(More)
BACKGROUND Sorafenib is a newly established cancer drug found to be an effective systemic treatment for advanced hepatocellular carcinoma (HCC). However, little is known about any potential effectors that modify tumor cell sensitivity towards sorafenib. Here, we present the first evidence that glucose-regulated protein 78 (GRP78) is intimately associated(More)
BACKGROUND/AIMS Serum tumor markers were investigated as prognostic factors for recurrence in patients with gastric cancers. METHODOLOGY Preoperative serum levels of CEA, CA72-4, CA19-9, TPA and CA125 were sampled in 196 patients with gastric cancers undergoing curative surgery. The results were compared with the clinical recurrence and various(More)