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Sleep duration and risk of all-cause mortality: A flexible, non-linear, meta-regression of 40 prospective cohort studies.
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High CD3D/CD4 ratio predicts better survival in muscle-invasive bladder cancer
TLDR
The CD3D/CD4 ratio can be viewed as a prognostic marker and a rough measurement for the interaction between immune-effecting CD3+ TILs and immune-suppressing CD3−CD4+ cells in MIBC, and this interaction may play a particularly important role in anti-cancer immunity in basal-squamous tumors.
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APOBEC-mediated Mutagenesis as a Likely Cause of FGFR3 S249C Mutation Over-representation in Bladder Cancer.
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Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer
TLDR
It is shown that BCa cells presenting those different genetic alterations were sensitive to AhR inhibition, reinforcing the importance of APOBEC mutagenesis in BCa and challenging the dogma that all hotspot mutations are drivers and mostly gain-of-function mutations affecting oncogenes.
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Intrafascial versus interfascial nerve sparing in radical prostatectomy for localized prostate cancer: a systematic review and meta-analysis
TLDR
ITR-NS has better continence at 6 mo and 36 mo and better potency recovery at 6Mo and 12 mo postoperatively, regardless of the surgical technique, and the cancer control of ITR-NS was also better than that of ITE-NS.
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Systematic review and meta-analysis on phosphodiesterase 5 inhibitors and α-adrenoceptor antagonists used alone or combined for treatment of LUTS due to BPH
TLDR
The novel data demonstrated that PDE5-Is plus ABs ranked the highest on the improvement of LUTS/BPH, and both combined- or mono-therapy were safe.
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TP53 codon 72 polymorphism and glioma risk: A meta-analysis.
TLDR
It is suggested that TP53 codon 72 polymorphism is associated with an increased risk of high-grade glioma development in Europeans.
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POLYMORPHIC DELETIONS OF GLUTATHIONE S-TRANSFERASES M1, T1 AND BLADDER CANCER RISK IN ALGERIAN POPULATION
TLDR
It is suggested that patients with cigarette smoking habit and combined GSTM1 and T1 genes deletion might be at increased risk of bladder cancer.
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Circulating tumor cells in breast cancer and its association with tumor clinicopathological characteristics: a meta-analysis
TLDR
The CTCs’ presence in PB is correlated with tumor size, tumor grade, ER, and PR, and correlation between nodal status and C TCs presence inPB is no statistically significant difference.
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The Role of COL5A2 in Patients With Muscle-Invasive Bladder Cancer: A Bioinformatics Analysis of Public Datasets Involving 787 Subjects and 29 Cell Lines
TLDR
Differential expression and co-expression network analysis suggested potential association between COL5A2 expression and essential pathways involved in cancer invasion and dissemination, including cell adhesion, extracellular matrix organization, and epithelial-mesenchymal transition.
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