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Retinal bipolar cells are essential to the transmission of light information. Although bipolar cell dysfunction can result in blindness, little is known about the factors required for bipolar cell development and functional maturation. The basic helix-loop-helix (bHLH) transcription factor Bhlhb4 was found to be expressed in rod bipolar cells (RB).(More)
A major unsolved question in cortical development is how proliferation, neurogenesis, regional growth, regional identity, and laminar fate specification are coordinated. Here we provide evidence, using loss-of-function and gain-of-function manipulations, that the COUP-TFI orphan nuclear receptor promotes ventral cortical fate, promotes cell cycle exit and(More)
Wireless sensor networks have often been used to monitor and report the locations of moving objects. Since sensors can also be used for storage, a wireless sensor network can be considered a distributed database, enabling us to update and query the location information of moving objects. Many researchers have studied the problem of how to construct(More)
Chicken ovalbumin upstream promotor-transcription factor I (COUP-TFI), an orphan member of the nuclear receptor superfamily, is highly expressed in the developing nervous systems. In the cerebral cortex of Coup-tfl mutants, cortical layer IV was absent due to excessive cell death, a consequence of the failure of thalamocortical projections. Moreover,(More)
Nuclear receptors play critical roles in the regulation of eukaryotic gene expression. We report the isolation and functional characterization of a novel transcriptional coactivator, termed steroid receptor RNA activator (SRA). SRA is selective for steroid hormone receptors and mediates transactivation via their amino-terminal activation function. We(More)
Transcriptional networks, which are initiated by secreted proteins, cooperate with each other to orchestrate eye development. The establishment of dorsal/ventral polarity, especially dorsal specification in the optic vesicle, is poorly understood at a molecular and cellular level. Here, we show that COUP-TFI (Nr2f1) and COUP-TFII (Nr2f2) are highly(More)
In this paper, we first propose a method, ABVCap, to construct a virtual coordinate system in a wireless sensor network. ABVCap assigns each node multiple 5-tuple virtual coordinates. Subsequently, we introduce a protocol, ABVCap routing, to route packets based on the ABVCap virtual coordinate system. ABVCap routing guarantees packet delivery without the(More)
The nuclear orphan receptor COUP-TFII is widely expressed in multiple tissues and organs throughout embryonic development, suggesting that COUP-TFII is involved in multiple aspects of embryogenesis. Because of the early embryonic lethality of COUP-TFII knockout mice, the role of COUP-TFII during limb development has not been determined. COUP-TFII is(More)
—In many applications, it is a basic operation for the sink to periodically collect reports from all sensors. Since the data gathering process usually proceeds for many rounds, it is important to collect these data efficiently, that is, to reduce the energy cost of data transmission. Under such applications, a tree is usually adopted as the routing(More)