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Retinal bipolar cells are essential to the transmission of light information. Although bipolar cell dysfunction can result in blindness, little is known about the factors required for bipolar cell development and functional maturation. The basic helix-loop-helix (bHLH) transcription factor Bhlhb4 was found to be expressed in rod bipolar cells (RB).(More)
Wireless sensor networks have often been used to monitor and report the locations of moving objects. Since sensors can also be used for storage, a wireless sensor network can be considered a distributed database, enabling us to update and query the location information of moving objects. Many researchers have studied the problem of how to construct(More)
A major unsolved question in cortical development is how proliferation, neurogenesis, regional growth, regional identity, and laminar fate specification are coordinated. Here we provide evidence, using loss-of-function and gain-of-function manipulations, that the COUP-TFI orphan nuclear receptor promotes ventral cortical fate, promotes cell cycle exit and(More)
A k-hop dominating set is a subset of nodes such that each node that is not in the set can be reached within k hops from at least one node in the set. A connected k-hop dominating set can be used for disseminating topology update packets or route request packets, in which the flooding search space is reduced to the set, resulting in significant flooding(More)
—In many applications, it is a basic operation for the sink to periodically collect reports from all sensors. Since the data gathering process usually proceeds for many rounds, it is important to collect these data efficiently, that is, to reduce the energy cost of data transmission. Under such applications, a tree is usually adopted as the routing(More)
Chicken ovalbumin upstream promotor-transcription factor I (COUP-TFI), an orphan member of the nuclear receptor superfamily, is highly expressed in the developing nervous systems. In the cerebral cortex of Coup-tfl mutants, cortical layer IV was absent due to excessive cell death, a consequence of the failure of thalamocortical projections. Moreover,(More)
The MapReduce/Hadoop architecture has become very important and effective in cloud systems because many data-intensive applications are usually required to process big data. In such environments, big data is partitioned and stored over several data nodes; thus, the total completion time of a task would be delayed if the maximum access latency among all(More)
Nuclear receptors play critical roles in the regulation of eukaryotic gene expression. We report the isolation and functional characterization of a novel transcriptional coactivator, termed steroid receptor RNA activator (SRA). SRA is selective for steroid hormone receptors and mediates transactivation via their amino-terminal activation function. We(More)
Arteries and veins are anatomically, functionally and molecularly distinct. The current model of arterial-venous identity proposes that binding of vascular endothelial growth factor to its heterodimeric receptor--Flk1 and neuropilin 1 (NP-1; also called Nrp1)--activates the Notch signalling pathway in the endothelium, causing induction of ephrin B2(More)
-This paper proves that deploying sensors on grid points to construct a wireless sensor network that fully covers critical grids using minimum sensors (Critical-Grid Coverage Problem) and that fully covers a maximum total weight of grids using a given number of sensors (Weighted-Grid Coverage Problem) are each NP-Complete.