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Nuclear receptors play critical roles in the regulation of eukaryotic gene expression. We report the isolation and functional characterization of a novel transcriptional coactivator, termed steroid receptor RNA activator (SRA). SRA is selective for steroid hormone receptors and mediates transactivation via their amino-terminal activation function. We(More)
Chicken ovalbumin upstream promotor-transcription factor I (COUP-TFI), an orphan member of the nuclear receptor superfamily, is highly expressed in the developing nervous systems. In the cerebral cortex of Coup-tfl mutants, cortical layer IV was absent due to excessive cell death, a consequence of the failure of thalamocortical projections. Moreover,(More)
The nuclear orphan receptor COUP-TFII is widely expressed in multiple tissues and organs throughout embryonic development, suggesting that COUP-TFII is involved in multiple aspects of embryogenesis. Because of the early embryonic lethality of COUP-TFII knockout mice, the role of COUP-TFII during limb development has not been determined. COUP-TFII is(More)
—In many applications, it is a basic operation for the sink to periodically collect reports from all sensors. Since the data gathering process usually proceeds for many rounds, it is important to collect these data efficiently, that is, to reduce the energy cost of data transmission. Under such applications, a tree is usually adopted as the routing(More)
Retinal bipolar cells are essential to the transmission of light information. Although bipolar cell dysfunction can result in blindness, little is known about the factors required for bipolar cell development and functional maturation. The basic helix-loop-helix (bHLH) transcription factor Bhlhb4 was found to be expressed in rod bipolar cells (RB).(More)
Disabled 1 (Dab1), a cytoplasmic adaptor protein expressed predominantly in the CNS, transduces a Reelin-initiated signaling that controls neuronal migration and positioning during brain development. To determine the role of Dab1 in neural stem cell (NSC) differentiation, we established a culture of neurospheres derived from the embryonic forebrain of the(More)
—A wireless sensor network has unidirectional links because sensors can have different transmission ranges, sensors have unstable transmission ranges, and a hidden terminal problem exists. In this paper, we introduce a virtual coordinate assignment protocol (ABVCap Uni) to assign virtual coordinates to nodes that have no geographic information in wireless(More)
In this paper, we first propose a method, ABVCap, to construct a virtual coordinate system in a wireless sensor network. ABVCap assigns each node multiple 5-tuple virtual coordinates. Subsequently, we introduce a protocol, ABVCap routing, to route packets based on the ABVCap virtual coordinate system. ABVCap routing guarantees packet delivery without the(More)