Learn More
A huge amount of research in academia and industry has focused on the hardware and technological side of information systems, while the role of emotions in the way these systems are utilized has been largely neglected. However, recent developments in other disciplines have suggested that emotions play a significant role in decision-making. To address this(More)
Can websites be designed to be both utilitarian and hedonic? This article approaches this question by identifying Web attributes, their direct impacts on experiential flow, and their direct and indirect impacts on the utilitarian and hedonic aspects of Web performance. The results presented here support the proposal that, as an information-laden medium, a(More)
Genistein, a natural isoflavanoid phytoestrogen, is thought to be the active ingredient in soy that possesses breast cancer preventive properties. The molecular mechanisms that are involved in its cancer preventive properties have not been completely understood. The present study is designed to investigate the mechanism involved in the inhibitory action of(More)
E-businesses using enterprise resource planning systems as the information infrastructure generate a tremendous amount of information, including information about customers, suppliers, markets, transaction costs, the prices at which products are bought and sold, and order-fulfillment rates, etc. To turn the information contained in these systems into(More)
AIM Hepatic stellate cell (HSC) plays a pivotal role in liver fibrosis and is considered as the therapeutic target for the treatment of hepatic fibrosis. Tyrosine protein kinase plays an important role in the proliferation, activation of HSC. The purpose of the study is to investigate the effects of the tyrosine protein kinase inhibitor genistein on the(More)
Okadaic acid (OA) is a tumor promoter in two-stage carcinogenesis experiments. Nevertheless, the effects of OA on cell transformation, cell proliferation and apoptosis vary widely, and the molecular events underlying these effects of OA are not well understood. In the present study, we examined the promoting activity and the associated effects on cell(More)
We demonstrate that the steady state reaction of lysine 5,6-aminomutase with substrate analogue 4-thia-l-lysine generates a radical intermediate, which accumulates in the enzyme to an electron paramagnetic resonance (EPR) detectable level. EPR line width narrowing of approximately 1 mT due to [4'-(2)H] labeling of the pyridoxal-5'-phosphate (PLP), an(More)
This article documents an e!ort to experimentally examine the e!ects of information characteristics of Web shopping sites on consumers' desire to approach the sites. A "eld experiment was conducted in which respondents visited shopping sites characterized by varying levels of information load. Two dimensions of information load, complexity and novelty were(More)
OBJECTIVE To evaluate the effects of selective and non-selective cyclooxygenase-2 on the growth and apoptosis of colon cancer cell lines in vitro. METHODS The proliferation of colon cancer cells was determined by MTT assay, and the cell cycle progression was analyzed by flow cytometric assay. Annexin V/PI staining in combination with flow cytometric assay(More)