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Alterations of mitochondrial DNA (mtDNA) have been associated with the risk of a number of human cancers; however, the relationship between mtDNA copy number in peripheral blood leukocytes (PBLs) and the risk of prostate cancer (PCa) has not been investigated. In a case-control study of 196 PCa patients and 196 age-paired healthy controls in a Chinese Han(More)
A natural serum autoantibody specific for the Thy-1 glycoprotein (anti-Thy-1 autoantibody [ATA]) is produced by B-1 cells that are positively selected by self-antigen. Here, using ATA micro kappa transgenic mice we show that cells with this B cell receptor are negatively selected during bone marrow (BM) development. In a Thy-1 null environment, BM ATA B(More)
Mouse CD1d1 molecules present endogenous glycolipids to NKT cells. Although glycolipid presentation requires CD1d1 transport through the endocytic pathway, the processing requirements for such endogenous Ag presentation by CD1d1 molecules are undefined. We examined CD1d1 Ag presentation to NKT cells by disrupting endocytic trafficking and function in cells(More)
Quan Qiu, Ze Zheng, Lin Chang, Yuan-Si Zhao, Can Tan, Aditya Dandekar, Zheng Zhang, Zhenghong Lin, Ming Gui, Xiu Li, Tongshuai Zhang, Qingfei Kong, Hulun Li, Sha Chen, An Chen, Randal J Kaufman, Wei-Lei Yang, Hui-Kuan Lin, Donna Zhang, Harris Perlman, Edward Thorp, Kezhong Zhang* and Deyu Fang* Department of Pathology, Northwestern University Feinberg(More)
To investigate the prevalence and the extent of coronary artery disease (CAD) in nondiabetic Chinese patients with different categories of impaired glucose regulation (IGR): isolated impaired fasting glucose (I-IFG); isolated impaired glucose tolerance (I-IGT); and combined IFG and IGT (CGI). A total of 556 nondiabetic subjects who had undergone coronary(More)
OBJECTIVE Quantitative measures are needed to identify diabetic patients at higher risk for CV events. Cell-derived microparticles (MPs) are submicron membrane vesicles released from activated cells that are indicative of cell damage. Progenitor cells (PCs) including proangiogenic cells (PACs), often termed endothelial progenitor cells (EPCs), are mediators(More)
The present study aimed to evaluate the efficacy and safety of combination of cyclophosphamide (CTX) and mycophenolate mofetil (MMF) as induction treatment in Chinese patients with class IV lupus nephritis (LN). 82 patients were randomly divided into control (CTX, n=40) and test (CTX+MMF, n=42) groups, and they received monthly dose of 0.75 g/m(2) of body(More)
OBJECTIVE To explore the clinical significance of interleukin (IL)-32 in the treatment of rheumatoid arthritis (RA) patients and analyze the correlations of IL-32 with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF). METHODS A total of 97 patients with RA and 36 patients with non-RA connective tissue diseases(More)
AIM To determine the effects of glycyrrhetinic acid (GA), methotrexate(MTX) and GA+MTX on the expressions of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in fibroblast-like synovial (FLS) cells from collagen induced arthritis (CIA) rats. METHODS CIA-FLS cells were isolated and purified from the synovium of CIA rats by tissue block culture(More)
Nicotinamide N-methyltransferase (NNMT) has been identified to be associated with tumorigenesis and the malignant transformation of numerous types of cancer. The aim of the present study was to explore the expression and prognostic significance of NNMT in prostate cancer (PCa). Immunohistochemical NNMT expression was examined in 26 cases of benign prostate(More)