Ming-Feng Chiang

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B-lymphocyte-induced nuclear maturation protein 1 (BLIMP1) was previously reported to define a sebaceous gland (SG) progenitor population in the epidermis. However, the recent identification of multiple stem cell populations in the hair follicle junctional zone has led us to re-evaluate its function. We show, in agreement with previous studies, that BLIMP1(More)
Dendritic cells (DCs) are important for the initiation and regulation of immune responses. In this study, we demonstrate that DC homeostatic development in peripheral lymphoid organs is negatively regulated by the transcriptional repressor, Blimp-1, which is critical for regulation of plasma cell differentiation and T cell homeostasis and function. Deletion(More)
In future high-speed photonic packet switching networks, it is highly desirable to carry out robust alloptical header recognition to provide high-throughput routing. The authors present a pulse-position modulation header processing (PPM-HP) scheme, offering significantly reduced routing table size and employing a single bitwise AND operation to carry out(More)
The 2009 H1N1 pandemic and recent human cases of H5N1, H7N9, and H6N1 in Asia highlight the need for a universal influenza vaccine that can provide cross-strain or even cross-subtype protection. Here, we show that recombinant monoglycosylated hemagglutinin (HAmg) with an intact protein structure from either seasonal or pandemic H1N1 can be used as a vaccine(More)
B lymphocyte-induced maturation protein-1 (Blimp-1) is a transcriptional repressor important for the differentiation and function of several types of immune cells. Because skin serves as a physical barrier and acts as an immune sentinel, we investigated whether Blimp-1 is involved in epidermal immune function. We show that Blimp-1 expression is reduced in(More)
In this paper we present the modeling and simulation of multiple-hop routing in ultrafast all-optical packet switching based routers employing multiple pulse position modulation (PPM) formatted routing table. In multiple PPM routing tables (PPRTs) with reduced entry length, only a subset of the header address is converted into a PPM format in order to(More)
Crosslinking of B-cell receptor (BCR) sets off an apoptosis programme, but the underlying pathways remain obscure. Here we decipher the molecular mechanisms bridging B-cell activation and apoptosis mediated by post-translational modification (PTM). We find that O-GlcNAcase inhibition enhances B-cell activation and apoptosis induced by BCR crosslinking. This(More)
This paper investigates the impact of a train of input Gaussian pulses wavelength on semiconductor optical amplifier (SOA) gain uniformity for high speed applications. In high speed applications, the linear output gain of the input pulses is necessary in order to minimize the gain standard deviation and power penalties. A segmentation model of the SOA is(More)
Abstract— This paper presents a high-speed multiple-channel optical time division multiplexed (OTDM) demultiplexer based on a chained symmetric Mach-Zehnder (CSMZ) switch. In CSMZ switch semiconductor optical amplifier (SOA) are shared between two chained arms in contrast to the MZ based multiple-channel demultiplexers where there is an SOA in each arm. The(More)
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