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  • Minal Garg
  • Expert opinion on therapeutic targets
  • 2015
INTRODUCTION Epithelial-to-mesenchymal transition (EMT) is a pathological phenomenon of cancer that confers tumor cells with increased cell motility, invasive and metastatic abilities with the acquisition of 'cancer stem-like cell' (CSC) phenotype. EMT endows tumor cells with intrinsic/acquired resistant phenotype at achievable doses of anticancer drugs and(More)
The process of epithelial to mesenchymal transition (EMT), first noted during embryogenesis, has also been reported in tumor formation and leads to the development of metastatic growth. It is a naturally occurring process that drives the transformation of adhesive, non-mobile epithelial like cells into mobile cells with a mesenchymal phenotype that have(More)
A small subset of cancer cells that act as tumor initiating cells or cancer stem cells (CSCs) maintain self-renewal and growth promoting capabilities of cancer and are responsible for drug/treatment resistance, tumor recurrence and metastasis. Due to their potential clinical importance, many researchers have put their efforts over decades to unravel the(More)
  • Minal Garg
  • Journal of experimental therapeutics & oncology
  • 2014
Urothelial carcinoma of bladder being the commonest malignancy of the urinary tract progresses through successive accumulation of genetic alterations and bears high metastatic potential. Despite significant advances in its prognosis and treatment, including surgical techniques, various adjuvant therapies, radical cystectomy and robot-assisted radical(More)
Urothelial carcinoma is a highly heterogeneous disease that develops along two distinct biological tracks as evident by candidate gene analysis and genome-wide screening and therefore, offers different challenges for clinical management. Tumors representing the truly distinct molecular entities express molecular markers characteristic of a developmental(More)
This review discusses the various regulatory characteristics of microRNAs that are capable of generating widespread changes in gene expression via post translational repression of many mRNA targets and control self-renewal, differentiation and division of cells. It controls the stem cell functions by controlling a wide range of pathological and(More)
INTRODUCTION Epithelial-to-mesenchymal transition (EMT) is a dynamic process in the pathogenesis of urinary bladder cancer. Despite significant advancements in its diagnosis and treatment, the outcomes have more or less remained the same. In the present study, the expression of EMT markers was investigated to evaluate its prognostic significance in patients(More)
Following genomic insults, inefficient DNA repair mechanisms may transform stem cell to cancer stem cells that have extensive self-renewal and aberrant differentiation properties rendering them highly resistant to chemotherapeutic and ionizing radiations and thus may cause tumor relapse in patients. Mature microRNAs (miRNAs), new class of modulators are(More)
  • Minal Garg
  • Expert reviews in molecular medicine
  • 2017
Cancer metastasis occurs through local invasion of circulating tumour cells (CTCs), intravasation, transportation to distant sites, and their extravasation followed by colonisation at secondary sites. Epithelial-mesenchymal transition (EMT) is a normal developmental phenomenon, but its aberrant activation confers tumour cells with enhanced cell motility,(More)