Mina Thabet Kelleni

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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury worldwide. It covers a wide spectrum of hepatic disorders ranging from simple steatosis, through steatohepatitis (steatosis with inflammation), to cirrhosis. The molecular and cellular mechanisms underlying hepatic injury in NAFLD are not clear. Several evidences(More)
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury; however its therapeutic strategy has not been established yet. Nitro-aspirin (NO-aspirin) is a new molecule in which aspirin and a NO-donating group are covalently linked. This study investigated the potential protective effect of NO-aspirin on NAFLD. Experimental(More)
Doxorubicin (DOX) is a widely used antineoplastic drug whose efficacy is limited by its cardiotoxicity. The aim of this study was to investigate the possible protective role of the antidiabetic drugs metformin (250 mg/kg dissolved in DW p.o. for seven days) and sitagliptin (10 mg/kg dissolved in DW p.o. for seven days) in a model of DOX-induced (single dose(More)
Methotrexate (MTX) is a commonly used antineoplastic and anti-rheumatoid drug whose efficacy is limited by its hepatotoxicity. The aim of this study was to investigate the possible protective role of captopril (100 mg/kg/day, p.o. for seven days), an angiotensin converting enzyme inhibitor, and telmisartan (10 mg/kg/day p.o. for seven days), an angiotensin(More)
Corresponding author: Mina T Kelleni, Department of Pharmacology, Faculty of Medicine, Minia University, Egypt, E-mail: drthabetpharm@yahoo.com Received: March 10, 2017; Revised: March 20, 2017; Published: March 28, 2017 Copyright: © 2017 Kelleni MT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution(More)
Progressive systemic sclerosis (PSS) is an autoimmune generalized connective tissue disease that affects the skin as well as internal organs. I report a 4 years old Egyptian female patient who is suffering from PSS for more than one and a half years. A peculiar clinical picture has deceived some clinicians at an early stage and a quite rapid progression has(More)
Geriatric individuals suffering from Alzheimer’s disease are frequently co-treated for hypertension and/or diabetes. In the current research, we have explored the addition of nifedipine (1 mg/ kg), glibenclamide (0.45 mg/kg) to donepezil (0.75 mg/kg) in a rabbit model of high fat dietinduced hypertension and hyperlipidemia. Nifedipine was shown to improve(More)
I want to share with you these two images that may illustrate further this feeling. Few months ago, parents came to my clinic with their 7 years old very shy girl, the reason was obvious; for 3 years they’ve tried hard to cure her auto immune alopecia areata (AA) consulting many dermatologists in vain, and recently a doctor tried multiple ultra violet(More)
In the past few years, rituximab has been recognized as a safe and effective emerging treatment for autoimmune hemolytic anemia (AIHA) [1,2]. Rituximab was also considered as a preferred secondline therapy of warm antibody hemolytic anemia in adults in some major European centers and it was shown that second-line treatment with rituximab led to response(More)