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Urinary metabolic fingerprinting for amiodarone-induced phospholipidosis in rats using FT-ICR MS.
In the research and development for new therapeutic compounds, there has been a focus on detecting the changes of metabolites induced by drug administration and finding surrogate markers to assessExpand
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Time-course changes of hematology and clinical chemistry values in pregnant rats.
The aim of this study is to report how pregnancy alters hematology and clinical chemistry values in rats. Female and male Sprague-Dawley rats were mated; the day of copulation was designated as DayExpand
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Metabolic Fingerprinting in Toxicological Assessment Using FT-ICR MS
Detection of the toxicity of a candidate compound at an early stage of drug development is an emerging area of interest. It is difficult to determine all of the effects of metabolism of a compoundExpand
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Urinary Metabolic Fingerprinting for α-naphthylisothiocyanate-induced Intrahepatic Cholestasis in Rats Using Fourier Transform-ion Cyclotron Resonance Mass Spectrometry
Urinary metabolic fingerprinting with Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS) was performed to monitor metabolic changes in an α-naphthylisothiocyanate (ANIT)-inducedExpand
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Urinary metabolic fingerprinting for thioacetamide-induced rat acute hepatic injury using fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS), with reference to detection of
In this study, we performed urinary metabolic fingerprinting using Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS) in the thioacetamide (TAA)-induced rat model of acuteExpand
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Metabolic fingerprinting of amniotic fluid from the streptozotocin‐induced diabetic pregnant rat using Fourier transform‐ion cyclotron resonance mass spectrometry
ABSTRACT  Metabolic fingerprinting of amniotic fluid from streptozotocin‐induced diabetic pregnant rats was performed using Fourier transform‐ion cyclotron resonance mass spectrometry. Some of theExpand
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Effects of Nanpao, a Kampo medicine, on the decline in estrous cyclicity with advancing age in female rats, as measured by vaginal impedance methods.
The present study was designed to evaluate the time-dependent effects of Nanpao, a kampo medicine, on age-related changes in the estrous cycle of female rats, and to investigate the utility ofExpand
Alternations of phospholipid profile in placenta of streptozotocin‐induced diabetic rat
Phospholipids have important roles in many biological processes, but their role in fetal malformation in pregnancy in diabetes is unclear. Metabolic fingerprinting of placental phospholipids inExpand