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Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter.(More)
—In this letter, we consider a two-way relay channel (TWRC) with two end nodes and k relay nodes, where end nodes have the full channel-state information (CSI) and relay nodes only have the channel-amplitude information (CAI). With the objective of minimizing transmit power consumption at required end-to-end rates, energy-efficient relay selection (RS) and(More)
Glia show marked heterogeneity in terms of electrophysiology in the developing brain, and two major types can be identified based on GFAP or NG2 expression. However, it remains to be determined if such an electrophysiological diversity holds for the adult brain and how GFAP and NG2 lineage glia are associated with different electrophysiological phenotypes(More)
Targeted gene silencing by RNAi requires the RNA-induced silencing complex (RISC), whose core component is the protein Argonaute (Ago) bound to a microRNA (miRNA) or an siRNA. In humans, Ago2 is loaded with miRNAs by the action of a specialized assembly called the RISC-loading complex (RLC), comprising the proteins Ago2, Dicer, and TRBP. Here we show that(More)
—MapReduce is becoming the state-of-the-art computing paradigm for processing large-scale datasets on a large cluster with tens or thousands of nodes. It has been widely used in various fields such as e-commerce, Web search, social networks, and scientific computation. Understanding the characteristics of MapReduce workloads is the key to achieving better(More)
The eukaryotic initiation factor 3 (eIF3) plays an important role in translation initiation, acting as a docking site for several eIFs that assemble on the 40S ribosomal subunit. Here, we use mass spectrometry to probe the subunit interactions within the human eIF3 complex. Our results show that the 13-subunit complex can be maintained intact in the gas(More)
Implicit methods for partial differential equations using unstructured meshes allow for an efficient solution strategy for many real-world problems (e.g., simulation-based virtual surgical planning). Scalable solvers employing these methods not only enable solution of extremely-large practical problems but also lead to dramatic compression in(More)
—Understanding the characteristics of MapReduce workloads in a Hadoop cluster is the key to making optimal configuration decisions and improving the system efficiency and throughput. However, workload analysis on a Hadoop cluster, especially in a large-scale e-commerce production environment, has not been well studied yet. In this paper, we performed a(More)