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Measurements of agreement are needed to assess the acceptability of a new or generic process, methodology, and formulation in areas of laboratory performance, instrument or assay validation, method comparisons, statistical process control, goodness of t, and individual bioequivalence. In all of these areas, one needs measurements that capture a large(More)
P2X(7) receptors are non-selective cation channels gated by extracellular ATP. Prolonged stimulation of the P2X(7) receptor leads to an increase in cell permeability, cytokine release and apoptosis/necrosis. Application of PIP(2) to inside-out patches strongly activated all homomeric members of the P2X receptor family, including P2X(7) channels. Blockade of(More)
Triterpenoids extracted from Ganoderma lucidum (Leyss. ex Fr.) Karst were separated and characterized using optimized reversed-phase liquid chromatography with diode array detection and electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MS(n)). They could be classified into five types depending on the fragmentation behavior. All triterpenoids gave(More)
OBJECTIVE Epidemiological studies of primary Sjögren's syndrome (pSS) are crucial for describing the burden to society and the public medical system and for shedding light on aetiology. Previous reports of the epidemiology of pSS show variable outcomes. We conducted a systematic review of the epidemiology of pSS to assess the prevalence rates (PRs) and(More)
OBJECTIVE To identify the genetic defects of the the adiponectin (APM1) gene that contribute to the development of type 2 diabetes (T2DM) and determine the functional single nucleotide polymorphisms (SNPs) in the APM1 gene associated with T2DM in Han nationality. METHODS The APM1 gene 5'-UTR was screened by direct sequencing to identify common(More)
Casticin, a component from Vitex rotundifolia, widely used as an anti-inflammatory agent in Chinese traditional medicine, was reported to have anti-tumor activities. This study aims to examine the anti-leukemic activity of casticin on leukemia cells and its molecular mechanism. Cell viability was measured by MTT method; apoptosis and cell cycle arrest were(More)
Peer-to-peer overlay networks are widely used in distributed systems. Based on whether a regular topology is maintained among peers, peer-to-peer networks can be divided into two categories: structured peer- to-peer networks in which peers are connected by a regular topology, and unstructured peer-to-peer networks in which the topology is arbitrary.(More)
The varicella-zoster virus (VZV) major transactivator, IE62, is involved in the expression of all kinetic classes of VZV genes and can also activate cellular promoters, promoters from heterologous viruses, and artificial promoters containing only TATA elements. A key component of the mechanism of IE62 transactivation is an acidic activation domain(More)
In this paper, we present an improved method of anchor models for speaker verification. Anchor model is the method that represent a speaker by his relativity of a set of other speakers, called anchor speakers. It was firstly introduced for speaker indexing in large audio database. We suggest a rank based metric for the measurement of speaker character(More)