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The Wisconsin Multifacet Project has created a simulation toolset to characterize and evaluate the performance of multiprocessor hardware systems commonly used as database and web servers. We leverage an existing full-system functional simulation infrastructure (Simics [14]) as the basis around which to build a set of timing simulator modules for modeling(More)
Debuggers have been proven indispensable in improving software reliability. Unfortunately, on most real-life software, debuggers fail to deliver their most essential feature --- a faithful replay of the execution. The reason is non-determinism caused by multithreading and non-repeatable inputs. A common solution to faithful replay has been to record the(More)
Now at VMware. Multithreaded deterministic replay has important applications in cyclic debugging, fault tolerance and intrusion analysis. Memory race recording is a key technology for multithreaded deterministic replay. In this paper, we considerably improve our previous always-on Flight Data Recorder (FDR) in four ways: <b>&#8226;Longer recording</b> by(More)
We aim to improve reliability of multithreaded programs by proposing a dynamic detector that detects potentially erroneous program executions and their causes. We design and evaluate a <i>Serializability Violation Detector</i> (SVD) that has two unique goals: (I) triggering automatic recovery from erroneous executions using backward error recovery (BER), or(More)
The bacterial pathogen Xanthomonas campestris pv. campestris co-ordinates virulence factor production and biofilm dispersal through a diffusible signal factor (DSF)-mediated cell-cell communication mechanism. The RpfC/RpfG two-component system plays a key role in DSF signal transduction and appears to modulate downstream DSF regulon by changing(More)
UNLABELLED The strong restriction barrier present in Staphylococcus aureus and Staphylococcus epidermidis has limited functional genomic analysis to a small subset of strains that are amenable to genetic manipulation. Recently, a conserved type IV restriction system termed SauUSI (which specifically recognizes cytosine methylated DNA) was identified as the(More)
To explore the clinical significance of seven diabetes-related serum microRNAs (miR-9, miR-29a, miR-30d, miR34a, miR-124a, miR146a and miR375) during the pathogenesis of type 2 diabetes (T2D), 56 subjects were recruited to this study: 18 cases of newly diagnosed T2D (n-T2D) patients, 19 cases of pre-diabetes individuals (impaired glucose tolerance [IGT](More)
We study graph estimation and density estimation in high dimensions, using a family of density estimators based on forest structured undirected graphical models. For density estimation, we do not assume the true distribution corresponds to a forest; rather, we form kernel density estimates of the bivariate and univariate marginals, and apply Kruskal’s(More)
BACKGROUND Many susceptible loci for type 2 diabetes mellitus (T2DM) have recently been identified from Caucasians through genome wide association studies (GWAS). We aimed to determine the association of 11 known loci with T2DM and impaired glucose regulation (IGR), individually and in combination, in Chinese. METHODS/PRINCIPAL FINDINGS Subjects were(More)