Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor alpha (ERalpha) binding sites in MCF-7 breast cancer cells. We identified 1,234… (More)
Chinese hamster ovary (CHO)–derived cell lines are the preferred host cells for the production of therapeutic proteins. Here we present a draft genomic sequence of the CHO-K1 ancestral cell line. The… (More)
0164-1212/$ see front matter 2008 Elsevier Inc. A doi:10.1016/j.jss.2008.06.001 * Corresponding author. Tel.: +65 83442816. E-mail address: liyanfu@nus.edu.sg (Y.F. Li). A number of software cost… (More)
The kinase TAK1 is critical for innate and B cell immunity. The function of TAK1 in T cells is unclear, however. We show here that T cell–specific deletion of the gene encoding TAK1 resulted in… (More)
Hypertrophic growth is a risk factor for mortality in heart diseases. Mechanisms are lacking for this global increase in RNA and protein per cell, which underlies hypertrophy. Hypertrophic signals… (More)
A new lifetime distribution capable of modeling a bathtub-shaped hazard-rate function is proposed. The proposed model is derived as a limiting case of the Beta Integrated Model and has both the… (More)
Grid computing system is different from conventional distributed computing systems by its focus on large-scale resource sharing, where processors and communication have significant influence on grid… (More)