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Dopamine (DA) D1 receptor (D1R) stimulation in prefrontal cortex (PFC) produces an 'inverted-U' dose-response, whereby either too little or too much D1R stimulation impairs spatial working memory. This response has been observed across species, including genetic linkages with human cognitive abilities, PFC activation states and DA synthesis. The cellular(More)
Query optimization is an integral part of relational database management systems. One important task in query optimization is selectivity estimation, that is, given a query <italic>P</italic>, we need to estimate the fraction of records in the database that satisfy <italic>P</italic>. Many commercial database systems maintain histograms to approximate the(More)
Prefrontal neurons engaged by working memory tasks express a sequence of phasic and tonic activations linked to a train of sensory, mnemonic, and response-related events. Here, we report that the dopamine D2 receptor selectively modulates the neural activities associated with memory-guided saccades in oculomotor delayed-response tasks yet has little or no(More)
Spatial working memory (WM; i.e., "scratchpad" memory) is constantly updated to guide behavior based on representational knowledge of spatial position. It is maintained by spatially tuned, recurrent excitation within networks of prefrontal cortical (PFC) neurons, evident during delay periods in WM tasks. Stimulation of postsynaptic alpha2A adrenoceptors(More)
Computing multidimensional aggregates in high dimensions is a performance bottleneck for many OLAP applications. Obtaining the exact answer to an aggregation query can be prohibitively expensive in terms of time and/or storage space in a data warehouse environment. It is advantageous to have fast, approximate answers to OLAP aggregation queries. In this(More)
There has recently been an explosion of interest in the analysis of data in data warehouses in the eld of On-Line Analytical Processing (OLAP). Data warehouses can be extremely large, yet obtaining quick answers to queries is important. In many situations, obtaining the exact answer to an OLAP query is prohibitively expensive in terms of time and/or storage(More)
Twitter has become an increasingly important source of information, with more than 400 million tweets posted per day. The task to link the named entity mentions detected from tweets with the corresponding real world entities in the knowledge base is called tweet entity linking. This task is of practical importance and can facilitate many different tasks,(More)
The National Institute of Standards and Technology (NIST) has announced that one of the design criteria for the Advanced Encryption Standard (AES) algorithm was the ability to efficiently implement it in hardware and software. Digital Signal Processors (DSPs) are a highly attractive option for software implementations of the AES finalists since they perform(More)
Multi-way Theta-join queries are powerful in describing complex relations and therefore widely employed in real practices. However, existing solutions from traditional distributed and parallel databases for multi-way Theta-join queries cannot be easily extended to fit a shared-nothing distributed computing paradigm, which is proven to be able to support(More)
  • Min Wang, Yang Yang, Ching-Jung Wang, Nao J. Gamo, Lu E. Jin, James A. Mazer +3 others
  • 2013
Neurons in the primate dorsolateral prefrontal cortex (dlPFC) generate persistent firing in the absence of sensory stimulation, the foundation of mental representation. Persistent firing arises from recurrent excitation within a network of pyramidal Delay cells. Here, we examined glutamate receptor influences underlying persistent firing in primate dlPFC(More)