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Although, in principle, gene expression profiling is well suited to isolate pathogenic molecules associated with Alzheimer's disease (AD), techniques such as microarray present unique analytic challenges when applied to disorders of the brain. Here, we addressed these challenges by first constructing a spatiotemporal model, predicting a priori how a(More)
463 was no malignant transformation at all, nor any local or distant metastasis. This case is the largest in size ever reported in the literature, measuring 21 cm × 17 cm × 12 cm. Although the radiological findings sug­ gested the involvement of the pericranium, surgical exploration and the management plan favored simple excision with a free margin and skin(More)
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