Learn More
In this editorial, the author explains that the journal Temperature stands on the shoulders of giants-prominent scientists of the past and current members of the Temperature community. Temperature also uses the best tools, such as Google Scholar profiles. The editorial includes a new puzzle: why does warm water freeze faster than cold water?
Amyloid plaques, a pathological hallmark of Alzheimer's disease (AD), are accompanied by activated microglia. The role of activated microglia in the pathogenesis of AD remains controversial: either clearing Aβ deposits by phagocytosis or releasing proinflammatory cytokines and cytotoxic substances. Microglia can be activated via toll-like receptors (TLRs),(More)
Amyloid plaque is the hallmark and primary cause of Alzheimer disease. Mutations of presenilin-1, the gamma-secretase catalytic subunit, can affect amyloid-beta (Abeta) production and Alzheimer disease pathogenesis. However, it is largely unknown whether and how gamma-secretase activity and amyloid plaque formation are regulated by environmental factors(More)
We describe a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with advantageous properties for clinical development, and its in vivo activity in preclinical alcoholism models. 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (MTIP) inhibited 125I-sauvagine binding to rat pituitary membranes(More)
Word sense disambiguation is the problem of selecting a sense for a word from a set of predefined possibilities. This is a significant problem in the biomedical domain where a single word may be used to describe a gene, protein, or abbreviation. In this paper, we evaluate SENSATIONAL, a novel unsupervised WSD technique, in comparison with two popular(More)
Recently, novel recommender systems have attracted considerable attention in the research community. Recommending popular items may not always satisfy users. For example, although most users likely prefer popular items, such items are often not very surprising or novel because users may already know about the items. Also, such recommender systems hardly(More)
Donald R. Gehlert,1 Andrea Cippitelli,2,4 Annika Thorsell,2 Anh Dzung Lê,3 Philip A. Hipskind,1 Chafiq Hamdouchi,1 Jianliang Lu,1 Erik J. Hembre,1 Jeffrey Cramer,1 Min Song,1 David McKinzie,1 Michelle Morin,1 Roberto Ciccocioppo,4 and Markus Heilig2 1Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285,(More)
PURPOSE This study evaluates the effect of dual PI3K and mTOR inhibition using NVP-BEZ235 in preclinical models of ovarian cancer as a potential novel therapeutic strategy. EXPERIMENTAL DESIGN Inhibition of PI3K/Akt/mTOR signaling by NVP-BEZ235 was demonstrated by immunoblotting. The effect on cell proliferation was assessed in 18 ovarian cancer cell(More)
A highly selective and sensitive HPLC-ESI-MS-MS method was developed for the determination of oleanolic acid in human plasma. The oleanolic acid and glycyrrhetinic acid (internal standard) were recovered from plasma with ethyl acetate liquid-liquid extraction. The organic extracts were dried under a stream of warm nitrogen, reconstituted in mobile phase and(More)
Product or company names used in this set are for identification purposes only. Inclusion of the names of the products or companies does not indicate a claim of ownership by IGI Global of the trademark or registered trademark. Handbook of research on text and web mining techologies / Min Song and Yi-Fang Wu, editors. p. cm. Includes bibliographical(More)