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Cul3, a Cullin family scaffold protein, is thought to mediate the assembly of a large number of SCF (Skp1-Cullin1-F-box protein)-like ubiquitin ligase complexes through BTB domain substrate-recruiting adaptors. Cul3 controls early embryonic development in several genetic models through mechanisms not understood. Very few functional substrate/adaptor pairs(More)
While many 3D objects exhibit various forms of global symmetries, prominent intrinsic symmetries which exist only on parts of an object are also well recognized. Such partial symmetries are often seen as more natural than a global one, even when the symmetric parts are under complex pose. We introduce an algorithm to extract <i>partial intrinsic(More)
We present a novel sketch-based tool, called iCutter (short for intelligent cutter), for cutting out semantic parts of 3D shapes. When a user performs a cutting task, he only needs to draw a freehand stroke to roughly specify where cuts should be made without much attention. Then, iCutter intelligently returns the best cut that meets the user's intention(More)
This paper presents an unsupervised algorithm for co-segmentation of a set of 3D shapes of the same family. Taking the over-segmentation results as input, our approach clusters the primitive patches to generate initial guess. Then, it iteratively builds a statistical model to describe each cluster of parts from previous estimation, and employs the(More)
This paper presents an extensive comparative evaluation of five popular foreground/background sketch-based interactive mesh segmentation algorithms, addressing the quantitative assessment of the accuracy, efficiency, and stability of each algorithm. To facilitate the comparison, we have developed a complete framework with an intuitive and simple(More)
Toxoplasma gondii is an obligate intracellular parasite that can pose a serious threat to human health by causing toxoplasmosis. There are no drugs that target the chronic cyst stage of this infection; therefore, development of an effective vaccine would be an important advance. Aspartic proteases play essential roles in the T. gondii lifecycle. The(More)
It is well established that brain-derived neurotrophic factor (BDNF) plays a pivotal role in brain plasticity-related processes, such as learning, memory and drug addiction. However, changes in expression of BDNF splice variants after acquisition, extinction and reinstatement of cue-elicited morphine seeking behavior have not yet been investigated.(More)
BACKGROUND Toxoplasma gondii is a widespread intracellular parasite, which infects most vertebrate animal hosts and causes zoonotic infection in humans. Vaccine strategy remains a promising method for the prevention and control of toxoplasmosis. T. gondii GRA4 protein has been identified as a potential candidate for vaccine development. In our study, we(More)