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Mutations in Parkin, an E3 ubiquitin ligase that regulates protein turnover, represent one of the major causes of familial Parkinson disease, a neurodegenerative disorder characterized by the loss of dopaminergic neurons and impaired mitochondrial functions. The underlying mechanism by which pathogenic Parkin mutations induce mitochondrial abnormality is(More)
In heterogeneous wireless networks, handoff can be separated into two parts: horizontal handoff (HHO) and vertical handoff (VHO). VHO plays an important role to fulfill seamless data transfer when mobile nodes cross wireless access networks with different link layer technologies. Current VHO algorithms mainly focus on when to trigger VHO, but neglect the(More)
The familial cylindromatosis tumor suppressor CYLD is known to contain three cytoskeleton-associated protein glycine-rich (CAP-Gly) domains, which exist in a number of microtubule-binding proteins and are responsible for their association with microtubules. However, it remains elusive whether CYLD interacts with microtubules and, if so, whether the(More)
Modern wheat (Triticum aestivum L.) is one of the most ozone (O(3))-sensitive crops. However, little is known about its genetic background of O(3) sensitivity, which is fundamental for breeding O(3)-resistant cultivars. Wild and cultivated species of winter wheat including donors of the A, B and D genomes of T. aestivum were exposed to 100 ppb O(3) or(More)
It is widely known that, for most natural images, appropriate contrast enhancement can usually lead to improved subjective quality. Despite of its importance to image processing, contrast change has largely been overlooked in the current research of image quality assessment (IQA). To fill this void, in this paper we first report a new and dedicated(More)
MicroRNAs (miRNAs) are important regulators of gene expression that are increasing being implicated in controlling plant development and its interaction with the environment. The advent of new high-throughput sequencing technologies has enabled both the discovery and quantification of miRNAs from a diverse range of species. In this study, we employed high(More)
The positive transcription elongation factor b (P-TEFb), consisting of Cdk9 and cyclin T, stimulates RNA polymerase II elongation and cotranscriptional pre-mRNA processing. To accommodate different growth conditions and transcriptional demands, a reservoir of P-TEFb is kept in an inactive state in the multisubunit 7SK snRNP. Under certain stress or disease(More)
Understanding the development of human brain organization is critical for gaining insight into how the enhancement of cognitive processes is related to the fine-tuning of the brain network. However, the developmental trajectory of the large-scale white matter (WM) network is not fully understood. Here, using graph theory, we examine developmental changes in(More)
Teachers' implementation of technology-enhanced student-centered learning environments (SCLEs) will be affected by their beliefs about effective practices. In order for student-centered programs to be used as intended, designers must be aware of the key issues that will shape their implementation and the beliefs teachers hold about these issues. This case(More)