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Homer Binds a Novel Proline-Rich Motif and Links Group 1 Metabotropic Glutamate Receptors with IP3 Receptors
Crystal Structure and Functional Analysis of the HERG Potassium Channel N Terminus A Eukaryotic PAS Domain
Accessory Protein Facilitated CFTR-CFTR Interaction, a Molecular Mechanism to Potentiate the Chloride Channel Activity
Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants.
KCNQ potassium channels are activated by changes in transmembrane voltage and play an important role in controlling electrical excitability. Human mutations of KCNQ2 and KCNQ3 potassium channel genes…
Differential trafficking of carboxyl isoforms of Ca2+‐gated (Slo1) potassium channels
Spatiotemporal Coupling of cAMP Transporter to CFTR Chloride Channel Function in the Gut Epithelia
Genetic isolation of transport signals directing cell surface expression
The genetically isolated SWTY motif is functionally interchangeable with a known motif in cardiac potassium channels and an identified motif in an HIV coreceptor, and operates by recruiting 14-3-3 proteins, and enables a screening method for membrane trafficking signals.
C‐terminal binding: An expanded repertoire and function of 14‐3‐3 proteins
Membrane receptor trafficking: Evidence of proximal and distal zones conferred by two independent endoplasmic reticulum localization signals
The distinctive operating ranges from their anchored membrane surface provide experimental evidence for the notion that there are functional zoning layers within which membrane protein signal motifs are active.
Applications of display technology in protein analysis
- Min Li
- BiologyNature Biotechnology
- 1 December 2000
The combination of an ever-increasing variety of libraries of modularly coded protein complexxes with the development of innovative approaches to select a wide array of desired properties has facilitated large-scale analyses of protein–protein/protein–substrate interactions.