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Power consumed by the memory system becomes a serious issue as the size of installed memory increases. With various low power modes that can be applied to each memory unit, the operating system can reduce the number of active memory units by collocating active pages onto a few memory units. This paper presents a memory management scheme based on this(More)
Virtualization technology enables server consolidation and has given an impetus to low-cost green data centers. However, current hypervisors do not provide adequate support for real-time applications, and this has limited the adoption of virtualization in some domains. Soft real-time applications, such as media-based ones, are impeded by components of(More)
The performance of modern many-core platforms strongly depends on the effectiveness of using their complex cache and memory structures. This indicates the need for a memory-centric approach to platform scheduling, in which it is the locations of memory blocks in caches rather than CPU idleness that determines where application processes are run. Using the(More)
BACKGROUND Intestinal epithelium is essential for maintaining normal intestinal homeostasis; its breakdown leads to chronic inflammatory pathologies, such as inflammatory bowel diseases (IBDs). Although high concentrations of S100A9 protein and interleukin-6 (IL-6) are found in patients with IBD, the expression mechanism of S100A9 in colonic epithelial(More)
As the trend of more cores sharing common resources on a single die and more systems crammed into enterprise computing space continue , optimizing the economies of scale for a given compute capacity is becoming more critical. One major challenge in performance scal-ability is the growing L2 cache contention caused by multiple contexts running on a(More)
The most widely validated animal models of the positive, negative and cognitive symptoms of schizophrenia involve administration of d-amphetamine or the open channel NMDA receptor blockers, dizocilpine (MK-801), phencyclidine (PCP) and ketamine. The drug ZJ43 potently inhibits glutamate carboxypeptidase II (GCPII), an enzyme that inactivates the peptide(More)
influenced by tuning its scheduler behavior using the weight, cap, and processor pinning variables. However, determining which parameters to tune and how to do that is non-trivial. In this paper, we introduce XenTune, a monitoring tool for the credit scheduler in Xen that helps in understanding application behavior in scheduler terms and assists in(More)
In attempts to elucidate the pathogenic mechanisms involved in neurodegeneration in AIDS patients with cognitive deficits, the possible effect of HIV-1 transmembrane envelope protein gp41 on expression of the membrane inhibitor of complement mediated cytolysis (CD59) was assessed in human neuronal (SK-N-SH) and astroglial (T98G) cell lines. Western blotting(More)
— There are two broad categories of approaches used for checkpointing: application-transparent and application-assisted. Typically, application-assisted approaches provide a more flexible and lightweight mechanism but require changes to the application. Although most applications run well under virtualization (e.g. Xen which is being adopted widely), the(More)