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Muscleblind participates in RNA toxicity of expanded CAG and CUG repeats in Caenorhabditis elegans
TLDR
These results provide the first experimental evidence to show that the RNA toxicity induced by expanded CAG and CUG repeats can be mediated, at least in part, through the functional alteration of muscleblind in worms.
Hippocampal neurogenesis after traumatic brain injury is mediated by vascular endothelial growth factor receptor-2 and the Raf/MEK/ERK cascade.
TLDR
VEGF plays an important role in neurogenesis after TBI, and that the process involves VEGF receptor-2 and the Raf/MEK/ERK cascade, as well as the effect of vascular endothelial growth factor (VEGF).
Organogenesis and tumorigenesis: Insight from the JAK/STAT pathway in the Drosophila eye
TLDR
The functions and regulation of the JAK/STAT pathway during eye development are focused on and some insights into the study of this pathway in tumorigenesis are provided.
Spatially controlled expression of the Drosophila pseudouridine synthase RluA-1.
TLDR
It is shown that the P-element of E7-2-36 inserts into the Drosophila RluA-1 gene, and the membrane-tethered green fluorescent protein driven by Rlu a-1-GAL4 was expressed in the dendritic arbors of MD neurons, confirming that Rlu A-1 is indeed expressed in MD neurons.
Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish
TLDR
The embryonic expression pattern of Drosophila, amphioxus, and zebrafish PRL genes is elucidated for the first time and suggests that PRL may play conserved roles in these animals for CNS development.
An Efficient Screen for Cell-Intrinsic Factors Identifies the Chaperonin CCT and Multiple Conserved Mechanisms as Mediating Dendrite Morphogenesis
TLDR
An efficient clonal screen using a collection of mapped P-element insertions that were previously shown to cause lethality and eye defects in Drosophila melanogaster reveals novel mechanisms underlying dendrite morphogenesis, and shows that CCT localizes in dendrites and is required for dendritic microtubule organization and tubulin stability.
Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila
TLDR
Uzip is identified as a novel CAM from the LG regulating axon guidance, which was mainly produced by the LG but was also located at axons, which is consistent with the secretion of Uzip expressed in cultured cells.
Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture
TLDR
Kud acts as a quality control mechanism for LINC-mediated nucleocytoskeletal connections and overexpression of the human orthologue TMEM258 in Drosophila proved functional conservation, expanding the understanding of the regulation of LINC complexes and NE architecture.
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