CD99 Regulates the Transport of MHC Class I Molecules from the Golgi Complex to the Cell Surface1
The results suggest that CD99 may be associated with the post-Golgi trafficking machinery by regulating the transport to the plasma membrane rather than the endocytosis of surface MHC class I molecules, providing a novel mechanism of M HC class I down-regulation for immune escape.
Suicide cancer gene therapy using pore-forming toxin, streptolysin O
- W. Yang, Sue-O Park, C. Kim
- Biology, ChemistryMolecular Cancer Therapeutics
- 1 June 2006
The results show that the genes of pore-forming toxins, like streptolysin O protein, have the potential to establish a novel class of suicide gene therapeutic reagents.
DC-SIGN expression in Hofbauer cells may play an important role in immune tolerance in fetal chorionic villi during the development of preeclampsia.
- S. Yang, E. Cho, Young‐Sun Kang
- Biology, MedicineJournal of Reproductive Immunology
- 1 November 2017
Targeted cytotoxic effect of anti-JL1 immunotoxin against a human leukemic cell line and its clinical implications
- Y. Shin, Yoon-La Choi, S. Park
- BiologyCancer Immunology and Immunotherapy
- 27 May 2003
Galonin-conjugated anti-JL1 mAb immunotoxin could be developed as a potential immunotherapeutic agent in the treatment of various types of JL1-positive acute leukemias.
MHC class II engagement inhibits CD99‐induced apoptosis and up‐regulation of T cell receptor and MHC molecules in human thymocytes and T cell line
- Min Kyung Kim, Yoon-La Choi, S. Park
- Biology, MedicineFEBS Letters
- 10 July 2003
Mutations of the immunoglobulin heavy chain variable region gene in CD99-deficient BJAB cell line.
- Y. H. Suh, Min Kyung Kim, S. Park
- BiologyMolecules and Cells
- 30 April 2002
It is reported that CD99 downregulated BJAB cell line has several mutations in IgH V genes, which might be the basis for the understanding of the molecular and cellular mechanism that regulate somatic mutation and B cell selection.
CD 99 expression is positively regulated by Sp 1 and is negatively regulated by Epstein-Barr virus latent membrane protein 1 through nuclear factor-k B
- Im-Soon Lee, Min Kyung Kim, S. Park
- Biology
- 2001
Data suggest that Sp1 activates, whereas LMP1 represses, transcription from the CD99 promoter through the NF-kB signaling pathway, and they might aid in the understanding of the molecular mechanisms of viral pathogenesis in EBVpositive Hodgkin disease.
Cell Surface I Molecules from the Golgi Complex to the CD99 Regulates the Transport of MHC Class
The results suggest that CD99 may be associated with the post-Golgi trafficking machinery by regulating the transport to the plasma membrane rather than the endocytosis of surface MHC class I molecules, providing a novel mechanism of M HC class I downregulation for immune escape.