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Suicide cancer gene therapy using pore-forming toxin, streptolysin O
The results show that the genes of pore-forming toxins, like streptolysin O protein, have the potential to establish a novel class of suicide gene therapeutic reagents.
CD99 Regulates the Transport of MHC Class I Molecules from the Golgi Complex to the Cell Surface1
The results suggest that CD99 may be associated with the post-Golgi trafficking machinery by regulating the transport to the plasma membrane rather than the endocytosis of surface MHC class I molecules, providing a novel mechanism of M HC class I down-regulation for immune escape.
Targeted cytotoxic effect of anti-JL1 immunotoxin against a human leukemic cell line and its clinical implications
Galonin-conjugated anti-JL1 mAb immunotoxin could be developed as a potential immunotherapeutic agent in the treatment of various types of JL1-positive acute leukemias.
DC-SIGN expression in Hofbauer cells may play an important role in immune tolerance in fetal chorionic villi during the development of preeclampsia.
It is speculated that fetal-derived Hofbauer cells may play an important role in normal pregnancy with immunosuppressive effects based on their M2 macrophage characteristics to maintain immune tolerance during pregnancy.
MHC class II engagement inhibits CD99‐induced apoptosis and up‐regulation of T cell receptor and MHC molecules in human thymocytes and T cell line
It is suggested that signaling via MHC class II on CD99‐engaged cells might be involved in the thymic maturation process by damping CD99 ligation effects.
Mutations of the immunoglobulin heavy chain variable region gene in CD99-deficient BJAB cell line.
It is reported that CD99 downregulated BJAB cell line has several mutations in IgH V genes, which might be the basis for the understanding of the molecular and cellular mechanism that regulate somatic mutation and B cell selection.
CD 99 expression is positively regulated by Sp 1 and is negatively regulated by Epstein-Barr virus latent membrane protein 1 through nuclear factor-k B
Epstein-Barr virus (EBV)–encoded latent membrane protein-1 (LMP1) is highly expressed in Hodgkin and Reed-Sternberg (H-RS) cells from patients with EBVassociated Hodgkin disease. It was previously