Min Ky Kim

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Huntington's disease is caused by CAG trinucleotide expansions in the gene encoding huntingtin. N- terminal fragments of huntingtin with polyglutamine produce aggregates in the endosome-lysosomal system, where proteolytic fragments of huntingtin is generated. Heat shock protein 70 (HSP70) prevents the formation of protein aggregates, but the effect of HSP70(More)
aeÁ√¯ø°º≠ »ƒ∫ OE ¿¸π ⁄««∫ OEΩ ≈ ∞ Ê ∞ ®∞ ¢Ω ≈ ∞ Ê¿¸µµ∞ ÀªÁ∏ ¶ Ω √« ‡«oe ø¥¥Ÿ. »Ø¿⁄¿« øÏ√¯ »ƒ∫ OE¿¸π ⁄««∫ OEΩ ≈ ∞ Ê¿« ∞ ®∞ ¢Ω ≈ ∞ Ê¿¸¿ßøÕ ∞ ®∞ ¢Ω ≈ ∞ Ê¿¸µµº " µµ¥¬ ¡ §ªÛ¿∏ ∑OE √¯¡ §µ«ae˙¿∏ ≥™ ¡¬√¯ø°º≠¥¬ ∞ ®∞ ¢Ω ≈ ∞ Ê¿¸¿ß∞ ° √¯¡ §µ«¡âe ae " ¥Ÿ(Fig. 2). « • ¿Áø‰∞ Ò∞ ®∞ ¢ Ω ≈ ∞ Ê¿¸µµ π ◊ ø‹√¯¿¸π ⁄««∫ OEΩ ≈ ∞ Ê ∞ ®∞ ¢Ω ≈ ∞ Ê¿¸µµ∞ ÀªÁ¥¬ aeÁ√¯ ø°º≠ ¡ §ªÛ¿OE º " ∞(More)
A 49 year-old woman, who took a high dose of disulfiram for the purpose of suicide, presented with severe hoarseness, quadriparesis, and sensory loss of distal limbs. Laryngeal electromyography showed ample denervation potentials. Nerve conduction study was consistent with severe sensorimotor axonal polyneuropathy. She was diagnosed with an acute palsy of(More)
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